LXX The Effects of Anesthetics upon the Ear II. Procaine Hydrochloride
LXX The Effects of Anesthetics upon the Ear II. Procaine Hydrochloride
复制标题
LXX 麻醉剂对耳朵的影响 II。
DOI：
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发表时间：
1960
期刊：
影响因子：
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通讯作者：
J. F. Crump
中科院分区：
文献类型：
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作者：
W. E. Rahm;W. F. Strother;W. L. Gulick;J. F. Crump
在早期的论文中指出，许多外科医生认为局部麻醉剂的使用是耳部手术的麻醉方法。Pitkin”指出了伴随表面麻醉的有利条件，Goodman和Gilman 4报道，局部麻醉药物的巨大实用价值来自于它们的作用是可逆的，并且随后神经功能完全恢复，对神经纤维或细胞没有明显的结构损伤。然而，现在有证据表明，某些目前使用的局部麻醉剂在手术过程中用于麻醉中耳结构时，会造成耳蜗反应的不可逆损失。根据听觉神经刺激的电假说，耳蜗电位的幅度的这种损失不能不对听力产生有害影响。虽然局部麻醉剂不会对神经纤维或细胞造成结构性损伤，但这些溶液显然会对耳蜗的微妙感觉结构造成严重损伤。因此，耳科手术麻醉的选择是一个重要的问题，需要非常仔细的研究。
In an earlier paper' it was pointed out that the use of topical anesthetics is considered by many surgeons to be the anesthetic method of choice for operations on the ear. Pitkin" indicated the favorable conditions accompanying topical anesthesia, and Goodman and Gilman 4 report that the great practical value of local anesthetic drugs arises from the fact that their action is reversible and is followed by complete recovery of nerve function with no evident structural dam age to nerve fibers or cells. Nevertheless, evidence now points to the fact that certain currently used local anesthetics produce irreversible losses in the cochlear response when these solutions are employed to anesthetize middle ear structures during surgery. According to the electrical hypothesis of auditory nerve stimulation, such losses in the magnitude of the cochlear potential cannot help but have deleterious effects upon hearing. It is possible that while local anesthetics do not cause structural damage to nerve fibers or cells these solutions apparently cause serious damage to the delicate sensory structures of the cochlea. Accordingly, the choice of anesthesia for otological surgery is an important matter, and one which needs very careful study.