FDG PET/CT for assessing tumour response to immunotherapy : Report on the EANM symposium on immune modulation and recent review of the literature.

FDG PET/CT for assessing tumour response to immunotherapy : Report on the EANM symposium on immune modulation and recent review of the literature.
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FDG PET/CT评估肿瘤对免疫疗法的反应:关于免疫调节的EANM研讨会的报告和文献近期综述。

DOI:
10.1007/s00259-018-4171-4
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发表时间:
2019-01
影响因子:
9.1
通讯作者:
Lopci E
Lopci E
中科院分区:
医学1区
文献类型:
--
作者:
Aide N;Hicks RJ;Le Tourneau C;Lheureux S;Fanti S;Lopci E

文献摘要

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本文是在欧洲核医学协会(EANM)2017年年会期间举行的免疫治疗研讨会上发表的。免疫检查点抑制剂的生物学基础和最常用于治疗实体瘤的药物进行了审查。假进展(频率,时间轴),超进展和免疫相关的副作用的问题进行了讨论,以及它们对患者管理的影响。本文回顾了最近关于使用FDG PET评估免疫治疗的文献,并根据已发表的数据和专家经验,提出了评估肿瘤反应和报告FDG PET免疫相关副作用的建议。本文还讨论了具有代表性的临床病例。
This paper follows the immunotherapy symposium held during the European Association of Nuclear Medicine (EANM) 2017 Annual Congress. The biological basis of the immune checkpoint inhibitors and the drugs most frequently used for the treatment of solid tumours are reviewed. The issues of pseudoprogression (frequency, timeline), hyperprogression and immune-related side effects are discussed, as well as their implications for patient management. A review of the recent literature on the use of FDG PET for assessment of immunotherapy is presented, and recommendations are provided for assessing tumour response and reporting immune-related side effects with FDG PET based on published data and experts’ experience. Representative clinical cases are also discussed.
DOI: 10.1038/nrc3239
发表时间: 2012-03-22
期刊: Nature reviews. Cancer
影响因子: --
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发表时间: 2017-08
影响因子: 9.1
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