Relationship between Controlled Attenuation Parameter and Hepatic Steatosis as Assessed by Ultrasound in Alcoholic or Nonalcoholic Fatty Liver Disease.
Relationship between Controlled Attenuation Parameter and Hepatic Steatosis as Assessed by Ultrasound in Alcoholic or Nonalcoholic Fatty Liver Disease.
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DOI：
10.5009/gnl15155
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发表时间：
2016-03
期刊：
影响因子：
3.4
通讯作者：
Yoo BC
中科院分区：
文献类型：
--
作者：
Ahn JM;Paik YH;Min SY;Cho JY;Sohn W;Sinn DH;Gwak GY;Choi MS;Lee JH;Koh KC;Paik SW;Yoo BC
本研究的目的是评估受控衰减参数 (CAP) 与肝脏脂肪变性之间的关系，通过超声 (US) 对酒精性肝病 (ALD) 或非酒精性脂肪肝病 (NAFLD) 患者进行评估。回顾性地将经超声诊断为脂肪肝并测量 CAP 评分的 ALD 或 NAFLD 患者纳入本研究。 US评估肝脂肪变性程度分为轻度（S1）、中度（S2）和重度（S3）。总共纳入 186 名患者：106 名患有 NAFLD，80 名患有 ALD。关于肝脂肪变性，CAP评分与US显着相关（ρ=0.580，p<0.001），而NAFLD和ALD组之间没有显着差异（ρ=0.569，p<0.001；ρ=0.519，p<0.001；p=0.635）。使用 CAP，≥S2 和 ≥S3 脂肪变性的受试者工作特征曲线下面积非常好（分别为 0.789 和 0.843）。对于灵敏度≥90%，在所有患者以及每个 NAFLD 和 ALD 组中，检测 ≥S2 和 ≥S3 脂肪变性的 CAP 截止值之间的差距约为 35 dB/m。根据 US 的评估，在 ALD 和 NAFLD 中，CAP 评分与肝脂肪变性密切相关。
The aim of this study was to evaluate the relationship between controlled attenuation parameter (CAP) and hepatic steatosis, as assessed by ultrasound (US) in patients with alcoholic liver disease (ALD) or non-alcoholic fatty liver disease (NAFLD). Patients with either ALD or NAFLD who were diagnosed with fatty liver with US and whose CAP scores were measured, were retrospectively enrolled in this study. The degree of hepatic steatosis assessed by US was categorized into mild (S1), moderate (S2), and severe (S3). A total of 186 patients were included: 106 with NAFLD and 80 with ALD. Regarding hepatic steatosis, the CAP score was significantly correlated with US (ρ=0.580, p<0.001), and there was no significant difference between the NAFLD and ALD groups (ρ=0.569, p<0.001; ρ=0.519, p<0.001; p=0.635). Using CAP, area under receiver operating characteristic curves for ≥S2 and ≥S3 steatosis were excellent (0.789 and 0.843, respectively). For sensitivity ≥90%, CAP cutoffs for the detection of ≥S2 and ≥S3 steastosis were separated with a gap of approximately 35 dB/m in all patients and in each of the NAFLD and ALD groups. The CAP score is well correlated with hepatic steatosis, as assessed by US, in both ALD and NAFLD.