Predictors of survival in spinocerebellar ataxia type 2 population from Southern Italy
Predictors of survival in spinocerebellar ataxia type 2 population from Southern Italy
复制标题
意大利南部脊髓小脑共济失调 2 型人群的生存预测因素
DOI：
10.1007/s10072-018-3504-1
复制
发表时间：
2018
影响因子：
3.3
通讯作者：
A. Filla
中科院分区：
文献类型：
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作者：
A. Antenora;D. Bruzzese;M. Lieto;A. Roca;Maria Teresa Florio;S. Peluso;F. Saccà;G. De Michele;F. Santorelli;A. Filla
回顾性分析了1973年至2016年期间亲自观察的来自35个不同家族的118例脊髓小脑共济失调2型患者。数据收集时间点为2017年1月1日。31名患者被限制在轮椅上。使用轮椅的中位时间为21年（95% CI，17.5-24.6）。37名患者死亡。至死亡的中位时间为25年（95% CI，22.9-27.1）。CAG重复次数和首次访视时的共济失调评分影响到轮椅和死亡的时间。
One hundred-eighteen spinocerebellar ataxia type 2 patients from 35 distinct families personally observed between 1973 and 2016 were retrospectively reviewed. The time point of data collection was 1 January 2017. Thirty-one patients were confined to wheelchair. The median time to wheelchair was 21 years (95% CI, 17.5–24.6). Thirty-seven patients were deceased. The median time to death was 25 years (95% CI, 22.9–27.1). CAG repeat number and ataxia score at first visit influenced the time to wheelchair and death.