Genetic variation in strains of zebrafish (Danio rerio) and the implications for ecotoxicology studies
Genetic variation in strains of zebrafish (Danio rerio) and the implications for ecotoxicology studies
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DOI：
10.1007/s10646-008-0267-0
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发表时间：
2009-01-01
期刊：
影响因子：
2.7
通讯作者：
Tyler, C. R.
中科院分区：
文献类型：
--
作者：
Coe, T. S.;Hamilton, P. B.;Tyler, C. R.
有大量证据表明，在个人和群体两个层面上，遗传变异对行为、健康和对有毒物质的反应有重大影响。利用DNA微卫星，我们研究了几种常用的实验室品系的斑马鱼，斑马鱼，毒理学研究的模式物种的样品中的遗传变异。我们将遗传变异与来自孟加拉国的野生鱼类样本进行了比较。我们的研究结果表明，野生鱼比实验室菌株的遗传变异性，包括等位基因丰富度和预期的杂合性的几个措施，显着更多变。任何试图将生态毒理学实验室试验结果外推到野生种群的研究都应适当考虑到这种缺乏变异的情况。
There is substantial evidence that genetic variation, at both the level of the individual and population, has a significant effect on behaviour, fitness and response to toxicants. Using DNA microsatellites, we examined the genetic variation in samples of several commonly used laboratory strains of zebrafish, Danio rerio, a model species in toxicological studies. We compared the genetic variation to that found in a sample of wild fish from Bangladesh. Our findings show that the wild fish were significantly more variable than the laboratory strains for several measures of genetic variability, including allelic richness and expected heterozygosity. This lack of variation should be given due consideration for any study which attempts to extrapolate the results of ecotoxicological laboratory tests to wild populations.