Role of transdermal potential difference during iontophoretic drug delivery
Role of transdermal potential difference during iontophoretic drug delivery
复制标题
DOI：
10.1109/tbme.2004.828039
复制
发表时间：
2004-09-01
影响因子：
4.6
通讯作者：
Stefanovska, A
中科院分区：
文献类型：
--
作者：
Bandrivskyy, A;Bernjak, A;Stefanovska, A
在经皮离子电渗疗法期间已经测量了电位差，以建立与电流相反的电压对皮肤血流的影响。众所周知，即使在没有药物的情况下，离子电渗疗法电流有时也会产生增加的血流量。电压在这个过程中的作用进行了研究，通过单端测量（电极和身体之间）的电位差在离子电渗与100 μ A，20秒的电流脉冲通过去离子水，饱和20.4%的NaCl溶液，1%乙酰胆碱，和1%硝普钠。发现输送电流所需的电压变化的数量级小于这些不同电解质的电导差异，并且得出结论，至少对于本电流方案，电压本身不是增加血液流量的重要因素。
Potential differences have been measured during transdermal iontophoresis in order to establish the effect of voltage, as opposed to current, on cutaneous blood flow. It is known that, even in the absence of drugs, the iontophoresis current can sometimes produce increased blood flow. The role of voltage in this process is studied through single-ended measurements (between electrode and body) of the potential difference during iontophoresis with 100-muA, 20-s current pulses through deionized water, saturated 20.4% NaCl solution, 1% acetylcholine, and 1% sodium nitroprusside. It is found that the voltage needed to deliver the current varied by orders of magnitudes less than the differences in the conductance of these different electrolytes, and it is concluded that, at least for the present current protocol, the voltage as such is not an important factor in increasing the blood, flow.