Cerebral activation during hypnotically induced and imagined pain
Cerebral activation during hypnotically induced and imagined pain
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DOI：
10.1016/j.neuroimage.2004.04.033
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发表时间：
2004-09-01
期刊：
影响因子：
5.7
通讯作者：
Oakley, DA
中科院分区：
文献类型：
--
作者：
Derbyshire, SWG;Whalley, MG;Oakley, DA
慢性腰痛、非典型面部疼痛或纤维肌痛等疾病的可识别的物理原因的持续缺乏是疼痛医生和研究人员之间持续争议和沮丧的根源。人们普遍认为异常的大脑活动与这种疾病有关，但缺乏大脑独立产生痛苦体验的正式证明。在这里，我们使用催眠暗示来识别直接参与疼痛产生的大脑区域，以在没有任何有害刺激的情况下创造疼痛体验。与想象的疼痛相比，功能性磁共振成像（fMRI）显示，在这种催眠诱导（III）的丘脑和前扣带回（ACC），前额叶和顶叶皮质疼痛的经验显着的变化。这些研究结果与疼痛过程中来自伤害性来源的激活模式进行了很好的比较，并提供了人类将特定神经活动与疼痛体验的立即产生联系起来的第一个直接实验证据。(C)2004年爱思唯尔公司All rights reserved.
The continuing absence of an identifiable physical cause for disorders such as chronic low back pain, atypical facial pain, or fibromyalgia, is a source of ongoing controversy and frustration among pain physicians and researchers. Aberrant cerebral activity is widely believed to be involved in such disorders, but formal demonstration of the brain independently generating painful experiences is lacking. Here we identify brain areas directly involved in the generation of pain using hypnotic suggestion to create an experience of pain in the absence of any noxious stimulus. In contrast with imagined pain, functional magnetic resonance imaging (fMRI) revealed significant changes during this hypnotically induced (III) pain experience within the thalamus and anterior cingulate (ACC), insula, prefrontal, and parietal cortices. These findings compare well with the activation patterns during pain from nociceptive sources and provide the first direct experimental evidence in humans linking specific neural activity with the immediate generation of a pain experience. (C) 2004 Elsevier Inc. All rights reserved.