MRS of normal and impaired fetal brain development
MRS of normal and impaired fetal brain development
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DOI：
10.1016/j.ejrad.2005.11.021
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发表时间：
2006-02-01
影响因子：
3.3
通讯作者：
Cozzone, P
中科院分区：
文献类型：
--
作者：
Girard, N;Fogliarini, C;Cozzone, P
通过子宫内局部质子磁共振波谱（MRS）研究了人类胎儿大脑的大脑成熟。光谱是在 1.5 T 运行的临床 MR 系统上采集的。体相控阵线圈（四个线圈）与脊柱线圈（两个线圈）结合使用。标称感兴趣体积 (VOI) 的尺寸为 4.5 cm(3) (20 mm x 15 mm x 15 mm)。 MRS 采集是使用短回波时间和长回波时间（TE = 30 ms 和 135 ms）的自旋回波序列进行的，VOI 位于大脑半球半卵圆中心水平。随着年龄的增长，观察到肌醇和胆碱显着减少，N-乙酰天冬氨酸增加。这里报告的正常磁共振波谱数据将有助于确定大脑新陈代谢是否改变，特别是当在传统图像上观察到细微的解剖变化时。举例说明了 MRS 研究的胎儿大脑发育受损的一些例子。 (C) 2005 年，爱思唯尔爱尔兰有限公司出版。
Cerebral maturation in the human fetal brain was investigated by in Utero localized proton magnetic resonance spectroscopy (MRS). Spectra were acquired on a clinical MR system operating at 1.5 T. Body phased array coils (four coils) were used in combination with spinal coils (two coils). The size of the nominal volume of interest (VOI) was 4.5 cm(3) (20 mm x 15 mm x 15 mm). The MRS acquisitions were per-formed using a spin echo sequence at short and long echo times (TE = 30 ms and 135 ms) with a VOI located within the cerebral hemisphere at the level of the centrum semiovale.A significant reduction in myo-inositol and choline and an increase in N-acetylaspartate were observed with progressive age. The normal MR spectroscopy data reported here will help to determine whether brain metabolism is altered, especially when subtle anatomic changes are observed on conventional images. Some examples of impaired fetal brain development studied by MRS are illustrated. (C) 2005 Published by Elsevier Ireland Ltd.