Protective Effects of Growth Arrest-Specific Protein 6 (Gas6) on Sepsis-Induced Acute Kidney Injury
Protective Effects of Growth Arrest-Specific Protein 6 (Gas6) on Sepsis-Induced Acute Kidney Injury
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生长停滞特异性蛋白 6 (Gas6) 对脓毒症引起的急性肾损伤的保护作用
DOI：
10.1007/s10753-015-0282-2
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发表时间：
2016-04-01
期刊：
影响因子：
5.1
通讯作者：
Lu, Zhong-qiu
中科院分区：
文献类型：
--
作者：
Chen, Long-wang;Chen, Wei;Lu, Zhong-qiu
急性肾损伤（acute kidney injury，阿基）是脓毒症的严重并发症，病死率高.生长停滞特异性蛋白6（Gas 6）是生长停滞特异性基因6的蛋白产物，已显示具有抗凋亡作用以及促存活能力。在这里，我们研究了Gas 6对盲肠结扎穿孔（CLP）小鼠脓毒症相关阿基的影响。我们发现rmGas 6的施用显著降低了血清尿素氮和肌酐，并改善了脓毒症小鼠的存活率。此外，rmGas 6治疗减轻了CLP诱导的肾脏病理损伤。rmGas 6可降低肾组织凋亡指数和Bax的表达，上调Bcl-2的表达。这些数据表明，rmGas 6可用作脓毒症诱导的阿基的潜在治疗剂。
Acute kidney injury (AKI) is a serious complication of sepsis, which has a high mortality rate. Growth arrest-specific protein 6 (Gas6), the protein product of the growth arrest specific gene 6, has been shown to have an anti-apoptotic effect as well as pro-survival capability. Here, we investigated the effects of Gas6 on sepsis-associated AKI in mice subjected to cecal ligation and puncture (CLP). We found that the administration of rmGas6 significantly reduced serum urea nitrogen and creatinine and improved the survival of septic mice. Furthermore, the renal pathological damage induced by CLP was attenuated by rmGas6 treatment. Finally, rmGas6 reduced the renal tissue apoptotic index and the expression of Bax, while it upregulated the expression of Bcl-2. The data suggest that rmGas6 might be used as a potential therapeutic agent for sepsis-induced AKI.