Intravenous ceftriaxone compared with oral doxycycline for the treatment of Lyme neuroborreliosis
Intravenous ceftriaxone compared with oral doxycycline for the treatment of Lyme neuroborreliosis
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DOI：
10.1080/00365540510027228
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发表时间：
2005-07-01
影响因子：
--
通讯作者：
Strle, F
中科院分区：
文献类型：
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作者：
Borg, R;Dotevall, L;Strle, F
这项前瞻性、开放标签、非随机试验在斯洛文尼亚卢布尔雅那和瑞典哥德堡的大学传染病系进行，目的是比较头孢曲松或多西环素治疗莱姆病神经螺旋体病10-14天后脑脊液（CSF）单核细胞计数的动力学。卢布尔雅那29例患者每日静脉注射头孢曲松2 g，哥德堡36例患者每日口服强力霉素400 mg。研究方案包括治疗开始前和治疗开始后6-8周腰椎穿刺。治疗后脑脊液中位单核细胞计数显著下降(1.2 log（10)x10(6)/l）。假设两次腰椎穿刺之间的对数单核细胞计数线性回归，两种抗生素治疗之间没有显着差异。所有患者经治疗后均有明显改善。在6个月的随访中，接受头孢曲松治疗的患者中有23例（79%）完全康复，接受强力霉素治疗的患者中有26例（72%）完全康复。静脉注射头孢曲松或口服多西环素治疗莱姆病有效、安全、方便。
This prospective, open-label, non-randomized trial at the University Departments of Infectious Diseases in Ljubljana, Slovenia, and Goteborg, Sweden, was conducted to compare the kinetics of the cerebrospinal fluid (CSF) mononuclear cell count after 10-14 d of ceftriaxone or doxycycline for treatment of Lyme neuroborreliosis. 29 patients were treated with intravenous ceftriaxone 2 g daily in Ljubljana and 36 patients with oral doxycycline 400 mg daily in Goteborg. The study protocol included lumbar puncture before and 6-8 weeks after treatment initiation. There was a marked decrease (1.2 log(10)x10(6)/l) of the median CSF mononuclear cell count following treatment. With the assumption of a linear regression of the logarithmic mononuclear cell counts between the 2 lumbar punctures, no significant difference between the 2 antibiotic treatments could be found. All patients were clinically much improved after treatment. At 6 months follow-up 23 (79%) of the ceftriaxone- and 26 (72%) of the doxycycline-treated patients were completely recovered. Intravenous ceftriaxone or oral doxycycline was found to be effective, safe, and convenient for treatment of Lyme neuroborreliosis.