World Association for the Advancement of Veterinary Parasitology (WAAVP) Guideline: Anthelmintic combination products targeting nematode infections of ruminants and horses
World Association for the Advancement of Veterinary Parasitology (WAAVP) Guideline: Anthelmintic combination products targeting nematode infections of ruminants and horses
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DOI：
10.1016/j.vetpar.2012.09.004
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发表时间：
2012-11-23
影响因子：
2.6
通讯作者：
Vercruysse, Jozef
中科院分区：
文献类型：
--
作者：
Geary, Timothy G.;Hosking, Barry C.;Vercruysse, Jozef
抗蠕虫线虫种群的威胁日益增加，需要重新评估反刍家畜和马线虫控制的化疗策略。本文的目的是提供一个指导原则，用于评价在单一剂型中含有两种或多种驱虫活性成分的产品，用于治疗这些动物的线虫感染。目前，批准此类产品的监管政策因司法管辖区而异，世界兽医寄生虫学促进协会（W.A.A.V.P.）准则应使各项要求协调一致。本指南对所需的最低标准提出了明确的建议，但强调提交批准的复方驱虫药产品的注册档案必须符合现有驱虫药指南中已经确立的标准和实践。
Increasing threats from anthelmintic resistant nematode populations warrant and motivate a reappraisal of chemotherapeutic strategies for nematode control in ruminant livestock and horses. The objective of this paper is to present a guideline for the evaluation of products containing two or more constituent anthelmintic actives in a single dosage form for the treatment of nematode infections in these animals. At present, regulatory policies on the approval of such products vary across jurisdictions, and this World Association for the Advancement of Veterinary Parasitology (W.A.A.V.P.) guideline should enable the harmonization of the requirements. This guideline makes clear recommendations on the minimal standards needed, but stresses that registration dossiers for combination anthelmintic products submitted for approval must conform to the standards and practices already established in existing guidelines for anthelmintics.