The regulation of MMP targeting to invadopodia during cancer metastasis.
The regulation of MMP targeting to invadopodia during cancer metastasis.
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DOI：
10.3389/fcell.2015.00004
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发表时间：
2015
影响因子：
5.5
通讯作者：
Prekeris R
中科院分区：
文献类型：
--
作者：
Jacob A;Prekeris R
癌细胞从原发肿瘤扩散到远处，称为转移，是癌症患者死亡的主要原因。转移是一个非常复杂的细胞过程，涉及许多步骤，包括基底膜（BM）的破坏，以允许细胞通过组织的运动。BM破坏通过细胞外基质（ECM）的高度调节和局部重塑发生，其由称为侵袭伪足的结构的形成和基质金属蛋白酶（MMP）的靶向分泌介导。最近，侵袭伪足已经成为调节许多癌症转移的关键细胞结构。此外，靶向各种细胞骨架调节剂和MMPs已被证明在调节侵袭伪足功能中起主要作用。在这里，我们强调了最近的研究结果，在侵袭伪足的形成和功能的蛋白质靶向调节。
The dissemination of cancer cells from the primary tumor to a distant site, known as metastasis, is the main cause of mortality in cancer patients. Metastasis is a very complex cellular process that involves many steps, including the breaching of the basement membrane (BM) to allow the movement of cells through tissues. The BM breach occurs via highly regulated and localized remodeling of the extracellular matrix (ECM), which is mediated by formation of structures, known as invadopodia, and targeted secretion of matrix metalloproteinases (MMPs). Recently, invadopodia have emerged as key cellular structures that regulate the metastasis of many cancers. Furthermore, targeting of various cytoskeletal modulators and MMPs has been shown to play a major role in regulating invadopodia function. Here, we highlight recent findings regarding the regulation of protein targeting during invadopodia formation and function.
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影响因子：
11.4
作者：
Bravo-Cordero, Jose J.;Marrero-Diaz, Raquel;Montoya, Maria C.
通讯作者：
Montoya, Maria C.
影响因子：
3.3
作者：
Beaty BT;Sharma VP;Bravo-Cordero JJ;Simpson MA;Eddy RJ;Koleske AJ;Condeelis J
通讯作者：
Condeelis J
影响因子：
10.6
作者：
Edwards DR;Handsley MM;Pennington CJ
通讯作者：
Pennington CJ
影响因子：
4.8
作者：
Abram, CL;Seals, DF;Courtneidge, SA
通讯作者：
Courtneidge, SA
影响因子：
--
作者：
CHEN, WT
通讯作者：
CHEN, WT