Plasma glucocorticoid elevation and ultrastructural changes in the adenohypophysis of the male rat following prolonged exposure to stress.
Plasma glucocorticoid elevation and ultrastructural changes in the adenohypophysis of the male rat following prolonged exposure to stress.
复制标题
长期承受压力后，雄性大鼠腺垂体的血浆糖皮质激素升高和超微结构变化。
DOI：
10.1159/000122539
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发表时间：
1976
影响因子：
4.1
通讯作者：
K. Cairncross
中科院分区：
文献类型：
--
作者：
I. Pollard;J. R. Bassett;K. Cairncross
形态和超微结构研究表明，腺垂体中的细胞活动与皮质酮的循环水平有很好的相关性。在10天以上的时间里，腺垂体的所有嗜性细胞都观察到强烈的分泌活动；此后，细胞形态显示恢复到对照状态。然而，不同的嗜性细胞之间的适应程度是不同的。在最初的过度活动后，促肾上腺皮质激素活动在20天后恢复到对照水平。促甲状腺激素活性也被发现与对照活动相适应，但仅在40天后。在胃肌和促性腺激素中也观察到了类似的模式，最初的肥大在20天后恢复到对照水平；然而，此后观察到了抑制。然而，促黄体激素似乎是一个例外，因为它的活动水平在整个应激过程中都在增加。
A morphological and ultrastructural study is described which indicates that cellular activity in the adenohypophysis correlates well with the circulating levels of corticosterone. Intense secretory activity is observed in all tropic cells of the adenohypophysis over 10 days; thereafter the cellular morphology shows a return to the control condition. There are, however, differences in the degree of adaptation between the different tropic cells. After its initial hyperactivity, corticotrope activity returned to a control level by 20 days. Thyrotrope activity was also found to adapt to control activity, but only after 40 days. Similar patterns were observed in the stomatotrope and gonadotrope, where the initial hypertrophy returned to control levels by 20 days; thereafter, however, an inhibition was observed. The luteotrope however, seems to be an exception in that its level of activity increased throughout the duration of the stress procedure.