Relation of neuroleptic and anticholinergic medication to cognitive functions in schizophrenia.
Relation of neuroleptic and anticholinergic medication to cognitive functions in schizophrenia.
复制标题
精神安定药和抗胆碱能药物与精神分裂症认知功能的关系。
DOI：
10.1037//0021-843x.98.4.367
复制
发表时间：
1989
影响因子：
4.6
通讯作者：
Strauss,ME
中科院分区：
文献类型：
--
作者：
Spohn,HE;Strauss,ME
在这篇文章中，我们回顾了旨在研究抗精神病药物和抗胆碱能药物对精神分裂症患者认知过程影响的研究。这篇综述的动机是认识到药物治疗是精神分裂症心理学研究中的一个重要因素，考虑到在认知调查中研究的绝大多数患者同时服用这两种药物。我们发现抗精神病药物治疗与许多心理测量的有限正常化有关，而抗胆碱能药物似乎会破坏记忆的某些方面。在心理学研究中，受试者选择标准、研究设计和药物测量方法在评估可能的药物效应中具有重要意义。
In this article, we review research designed to examine the influence of neuroleptic and anticholinergic drugs on cognitive processes in schizophrenia. The review is motivated by the recognition that pharmacotherapy is an important factor in psychological research on schizophrenia, given that the great majority of patients studied in investigations of cognition receive both of these drugs. We find that neuroleptic treatment is associated with limited normalization on many psychological measures, whereas anticholinergics appear to disrupt some aspects of memory. Subject selection criteria, research designs, and drug measurement methods important in the evaluation of possible drug effects in psychological studies are discussed.