Social networks as drivers of syphilis and HIV infection among young men who have sex with men
Social networks as drivers of syphilis and HIV infection among young men who have sex with men
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DOI：
10.1136/sextrans-2017-053288
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发表时间：
2018-08-01
影响因子：
3.6
通讯作者：
Schneider, John A.
中科院分区：
文献类型：
--
作者：
Fujimoto, Kayo;Flash, Charlene A.;Schneider, John A.
目的梅毒和HIV流行重叠，但对梅毒-HIV合并感染的网络和行为因素知之甚少。我们的研究目的是评估网络环境和性行为与梅毒-艾滋病毒合并感染和单一感染之间的一个特别脆弱的亚组：年轻的黑人男性与男性发生性关系（YBMSM）。为了实现这一目标，我们检查了与梅毒-HIV感染状态分类的每个亚组的合并感染相关的因素：（A）HIV单一感染，（B）梅毒单一感染和（C）既没有梅毒感染也没有HIV感染。此外，我们进一步确定了与HIV感染或梅毒单infection.Methods数据收集的样本365 YBMSM，年龄16-29岁，通过响应者驱动的抽样招募2014年至2016年之间，在两个大的HIV流行病的城市：休斯顿，得克萨斯州，和芝加哥，IL。我们进行了一系列的多项逻辑回归模型来预测合并感染，HIV单感染和梅毒单感染的网络和性行为factors.Results的功能合并感染与网络成员谁是合并感染或HIV感染在一个人的社会网络。梅毒单感染与更多的社会场所出席，艾滋病毒单感染与有更多的无避孕套的顶级partners.Conclusion公共卫生干预措施，解决梅毒感染的诊断和治疗，并确保那些与梅毒正在进行艾滋病毒检测可能是有前途的限制梅毒-艾滋病毒感染的协同作用，在向前传播。在高流行率网络中推进艾滋病毒和梅毒预防工作可能会优先考虑有限的资源。
Objectives Syphilis and HIV epidemics overlap, yet little is known about combined network and behavioural factors that drive syphilis-HIV coinfection. Our study objective was to assess network contexts and sexual behaviours associated with syphilis-HIV co-infection and monoinfection among a particularly vulnerable subgroup: young Black men who have sex with men (YBMSM). To achieve this objective, we examined factors associated with coinfection by each subgroup as classified by syphilis-HIV infection status: (A) HIV monoinfected, (B) syphilis monoinfected and (C) neither syphilis infected nor HIV infected. In addition, we further identified the factors that are associated with HIV infection or syphilis monoinfection.Methods Data were collected from a sample of 365 YBMSM, aged 16-29 years, recruited through respondent-driven sampling between 2014 and 2016, in two cities with large HIV epidemics: Houston, TX, and Chicago, IL. We conducted a series of multinomial logistic regression models to predict coinfection, HIV monoinfection and syphilis monoinfection as a function of network and sexual behavioural factors.Results Coinfection was associated with having network members who are coinfected or HIV infected within one's social network. Syphilis monoinfection was associated with a higher number of social venues attended, and HIV monoinfection was associated with having more condomless top partners.Conclusion Public health interventions that address the diagnosis and treatment of syphilis infection and ensure that those with syphilis are being tested for HIV may be promising in limiting the synergy of syphilis-HIV infections in onward transmission. Advancing HIV and syphilis prevention efforts in high-prevalence networks may allow prioritisation of limited resources.