The quantitative relationship between longitudinal and radial function in left, right, and total heart pumping in humans
The quantitative relationship between longitudinal and radial function in left, right, and total heart pumping in humans
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DOI：
10.1152/ajpheart.01376.2006
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发表时间：
2007-07-01
影响因子：
4.8
通讯作者：
Arheden, Hakan
中科院分区：
文献类型：
--
作者：
Carlsson, Marcus;Ugander, Martin;Arheden, Hakan
心脏收缩期的心脏总容积变化（THVV）被认为是由心室的径向功能引起的，但尚未提供两个心室的确切数据。此外，右心室（RV）被认为具有比左心室（LV）更大的纵向泵送分量。因此，我们的目的是比较由径向函数生成的每搏输出量（SV）与左、右和全心脏的容积变化。为此，我们还需要开发一种新的方法来测量纵向房室平面位移（AVPD）对RVSV（RVSVAVPD）的贡献。在我们的研究中，11名志愿者接受了短轴和长轴平面的电影MRI和所有通往和来自心脏的血管的MRI流量测量。左、右和全心显示出流量测量的容积变化与径向功能（SV减去纵向功能）之间的相关性（分别为r = 0.81，P < 0.01; r = 0.80，P < 0.01;和r = 0.92，P < 0.001）。与LV相比，RV的AVPD（23.4 +/- 0.8 vs. 16.4 +/- 0.5 mm）、容积中心移动（13.0 +/- 0.7 vs. 7.8 +/- 0.4 mm）和RVSVAVPD（82 +/- 2% vs. 60 +/- 2%）更大（均P < 0.001）。我们发现THVV主要是由心室的径向功能引起的。纵向AVPD约占RVSV的80%，而LVSV约占60%。这种差异解释了在心脏左侧发现的较大部分THVV。
The total heart volume variation (THVV) during systole has been proposed to be caused by radial function of the ventricles, but definitive data for both ventricles have not been presented. Furthermore, the right ventricle (RV) has been suggested to have a greater longitudinal pumping component than the left ventricle (LV). Therefore, we aimed to compare the stroke volume (SV) generated by radial function to the volume variation of the left, right, and total heart. To do this, we also needed to develop a new method for measuring the contribution of the longitudinal atrioventricular plane displacement (AVPD) to the RVSV (RVSVAVPD). For our study, 11 volunteers underwent cine MRI in the short- and long-axis planes and MRI flow measurement in all vessels leading to and from the heart. The left, right, and total heart showed correlations between volume variation from flow measurements and radial function calculated as SV minus the longitudinal function (r = 0.81, P < 0.01; r = 0.80, P < 0.01; and r = 0.92, P < 0.001, respectively). Compared with the LV, the RV had a greater AVPD (23.4 +/- 0.8 vs. 16.4 +/- 0.5 mm), center of volume movement (13.0 +/- 0.7 vs. 7.8 +/- 0.4 mm), and, RVSVAVPD (82 +/- 2% vs. 60 +/- 2%) (P < 0.001 for all). We found that THVV is predominantly caused by radial function of the ventricles. Longitudinal AVPD accounts for similar to 80% of the RVSV, compared with similar to 60% for the LVSV. This difference explains the larger portion of THVV found on the left side of the heart.