A randomized study of radiotherapy versus radiotherapy plus chemotherapy in stage I‐II non‐hodgkin's lymphomas
A randomized study of radiotherapy versus radiotherapy plus chemotherapy in stage I‐II non‐hodgkin's lymphomas
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DOI：
10.1002/1097-0142(19830701)52:1
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发表时间：
2006-06
期刊：
影响因子：
6.2
通讯作者：
N. Nissen;J. Ersbøll;H. S. Hansen;S. Walbom-jørgensen;J. Pedersen‐Bjergaard;M. Hansen;J. Rygård
中科院分区：
文献类型：
--
作者：
N. Nissen;J. Ersbøll;H. S. Hansen;S. Walbom-jørgensen;J. Pedersen‐Bjergaard;M. Hansen;J. Rygård
在 1974 年至 1978 年的一项随机前瞻性试验中，73 名临床 I 期或 II 期非霍奇金淋巴瘤患者接受单独大范围放疗 (RT) 或 RT 加长春新碱、链黑素、环磷酰胺和泼尼松辅助化疗 (RT + CT) 的治疗。中位随访时间为 5 年，RT 组中有 54% 的患者复发，而 RT + CT 组的复发率仅为 10%（P < 0.01）。总体生存率尚无统计学差异，但 RT 组中有 13/14 的死亡是由于疾病进展所致，而 RT + CT 组中只有 3/12 的死亡。在组织学不良的患者中，RT 组中有 13/22 人死于疾病进展，而 RT + CT 组中有 3/34 人死亡（P < 0.01）。结果与其他两个详细发布的系列的结果一致。因此，根据这些结果，我们建议对所有组织学不良的 I-II 期患者使用辅助 CT 联合放疗。对于组织学更有利的淋巴瘤患者，还需要进一步观察才能得出结论。癌症 52：1-7，1983 年。
In a randomized, prospective trial from 1974–1978, 73 patients with non‐Hodgkin's lymphomas in clinical Stage I or II were treated with extended field radiotherapy alone (RT) or RT plus adjuvant chemotherapy with vincristine, streptonigrin, cyclophosphamide and prednisone (RT + CT). With a median follow‐up time of five years, 54% have relapsed in the RT group versus only 10% in the RT + CT group (P < 0.01). There is no statistical difference in the overall survival yet, but 13/14 deaths in the RT group versus only 3/12 in the RT + CT group were due to progressive disease. Among patients with unfavorable histology, 13/22 in the RT group have died from disease progression against 3/34 in the RT + CT group (P < 0.01). The results are in agreement with those from two other series published in detail. Based on these results we therefore recommend to use adjuvant CT with RT in all Stage I‐II patients with unfavorable histology. Further observation is necessary before a conclusion can be drawn for the lymphoma patients with more favorable histology. Cancer 52:1–7, 1983.