Postmenopausal hormone therapy and stroke
Postmenopausal hormone therapy and stroke
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DOI：
10.1001/archinte.168.8.861
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发表时间：
2008-04-28
影响因子：
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通讯作者：
Rexrode, Kathryn
中科院分区：
文献类型：
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作者：
Grodstein, Francine;Manson, JoAnn E.;Rexrode, Kathryn
背景：我们评估了年轻女性、新近绝经女性和老年女性中与激素治疗(HT)相关的卒中风险。方法：采用两年一度的邮寄问卷，对1976-2004年间护士健康研究的绝经后参与者进行前瞻性观察分析。使用比例风险模型计算多变量调整后的相对风险(RR)和95%可信区间(CI)。结果：我们发现，目前服用HT的女性中风风险显著增加(单独服用雌激素：RR，1.39；95%CI，1.18-1.63；雌激素与孕激素联用：RR，1.27；95%CI，1.04-1，56)，这一发现与妇女健康倡议的结果几乎一致。观察到，在年轻或接近绝经的年龄，以及在年长或绝经后10年以上的女性中，启动高血压的风险增加。短期(
Background: We evaluated stroke risk associated with hormone therapy (HT) in younger women, in recently menopausal women, and in older women.Methods: Prospective, observational analyses were performed in postmenopausal participants of the Nurses' Health Study, from 1976 to 2004, with biennial mailed questionnaires. Proportional hazards models were used to calculate multivariable-adjusted relative risks (RRs) and 95% confidence intervals (CIs).Results: We found a significantly increased risk of stroke for women currently taking HT (estrogen alone: RR, 1.39; 95% CI, 1. 18-1.63; and estrogen with progestin: RR, 1.27; 95% CI, 1.04-1,56), a finding that is nearly identical to that of the Women's Health Initiative. This increased risk was observed for women initiating HT at young ages or near menopause and at older ages or more than 10 years after menopause. Short-term (