Towards an asymmetric synthesis of the bacterial peptide deformylase (PDF) inhibitor fumimycin
Towards an asymmetric synthesis of the bacterial peptide deformylase (PDF) inhibitor fumimycin
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DOI：
10.1039/b916372g
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发表时间：
2009-01-01
影响因子：
3.2
通讯作者：
Braese, Stefan
中科院分区：
文献类型：
--
作者：
Hartmann, Caroline E.;Gross, Patrick J.;Braese, Stefan
报道了细菌多肽变形酶(PDF)抑制剂伏米霉素的合成研究。该合成方法的特点是有机催化进入α，α-二取代氨基酸单元，并导致合成一种先进的中间体，该中间体已经包含了伏米霉素的所有功能。
Studies towards the synthesis of the bacterial peptide deformylase (PDF) inhibitor fumimycin are reported. The synthetic approach features an organocatalytic access to the alpha,alpha-disubstituted amino acid unit and results in the synthesis of an advanced intermediate which already contains all functionalities of fumimycin.