Parasympathetic and adrenergic contractile responses in canine trachea and bronchus.
Parasympathetic and adrenergic contractile responses in canine trachea and bronchus.
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犬气管和支气管的副交感神经和肾上腺素能收缩反应。
DOI：
10.1152/jappl.1983.55.1.113
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发表时间：
1983
期刊：
影响因子：
--
通讯作者：
S. Hendrix
中科院分区：
文献类型：
--
作者：
A. Leff;N. Muñoz;S. Hendrix
我们在26条犬的气管和三级支气管肌上同时比较了交感和副交感收缩反应。刺激5只犬双侧颈迷走神经产生刺激-反应曲线，以确定引起气管和支气管最大副交感神经收缩的参数(20V，15 Hz，2ms)。在6只肾上腺完整(ADI)犬和5只肾上腺切除(ADX)犬上，静脉注射碘化1，1-二甲基-4-苯基哌嗪(DMPP)，观察了毒扁豆碱和β-肾上腺素能阻断后交感神经介导的α-肾上腺素能收缩。在ADI犬，静脉注射DMPP的最大α-肾上腺素能收缩反应是气管最大副交感反应的67.3+/-14.8%，是支气管最大副交感反应的112+/-21%(P<0.03)。在阿昔洛韦犬，α-肾上腺素能/副交感神经最大刺激率在气管为17.6+/-1.3%，在支气管为41.4+/-2.5%(P<0.001)。在对气管和支气管的α-肾上腺素能和胆碱能反应的药理学研究中，也得到了类似的关系。我们得出结论，在气管和支气管中，胆碱能和α-肾上腺素能收缩特性在生理和药理上有很大的异质性。相对于胆碱能收缩，循环儿茶酚胺和交感神经在支气管引起的α-肾上腺素能收缩比对气管平滑肌引起的大得多。
We compared the sympathetic and parasympathetic contractile responses of tracheal and third-order bronchial smooth muscle simultaneously in 26 dogs in situ. Stimulus-response curves were generated by bilateral stimulation of the cervical vagus nerves in five dogs to determine the parameters (20 V, 15 Hz, 2-ms duration) causing maximal parasympathetic contraction in trachea and bronchus. In six adrenal-intact (ADi) and five adrenalectomized (ADx) dogs, sympathetically mediated alpha-adrenergic contraction was studied after muscarinic and beta-adrenergic blockade by administering intravenous (iv) 1,1-dimethyl-4-phenylpiperazinium iodide (DMPP). In ADi dogs, the maximal alpha-adrenergic contractile response to iv DMPP was 67.3 +/- 14.8% of the maximal parasympathetic response in trachea and 112 +/- 21% of the maximal parasympathetic response in bronchus (P less than 0.03). In ADx dogs, the maximal alpha-adrenergic-to-parasympathetic stimulation ratios were 17.6 +/- 1.3% in trachea and 41.4 +/- 2.5% in bronchus (P less than 0.001). Comparable relationships were also obtained in pharmacological studies of alpha-adrenergic and cholinergic responses in trachea and bronchus. We conclude that there is substantial heterogeneity in the physiological and pharmacological cholinergic and alpha-adrenergic contractile properties in trachea and bronchus. Relative to cholinergic contraction, both circulating catecholamines and sympathetic innervation cause substantially greater alpha-adrenergic contraction in bronchus than for tracheal smooth muscle.