[Effect of acupuncture on pattern-visual evoked potential in rats with monocular visual deprivation].
[Effect of acupuncture on pattern-visual evoked potential in rats with monocular visual deprivation].
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发表时间：
2013-08
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通讯作者：
Xingke Yan;Lili Dong;An-guo Liu;Jun-yan Wang;Chong-bing Ma;Tian-tian Zhu
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作者：
Xingke Yan;Lili Dong;An-guo Liu;Jun-yan Wang;Chong-bing Ma;Tian-tian Zhu
目的 探讨针刺治疗和预防视觉剥夺效应的电生理机制。
方法 将18只15日龄健康的伊文思大鼠随机分为正常组、模型组和针刺组，每组6只。模型组和针刺组采用单眼眼睑缝合的方法建立剥夺性弱视模型。针刺组选取“睛明”（BL1）、“承泣”（ST1）、“球后”（EX - HN7）和“攒竹”（BL2）进行针刺，双侧穴位交替选取，每日一侧，共14天。观察针刺对不同空间频率视觉诱发电位的影响。
方法 在2×2、4×4和8×8三种不同空间频率下，与正常组相比，模型组存在明显的视觉剥夺效应，P1峰潜伏期延迟（P<0.05）。在4×4空间频率下，正常组和针刺组的N1 - P1波幅值最大。在此空间频率下大鼠眼睛具有最佳分辨能力，表明其可能是大鼠视觉系统的最佳空间频率。
结论 视觉系统在敏感期具有明显的电生理可塑性。针刺治疗可调节视觉剥夺引起的视觉反应抑制和减慢，以对抗剥夺效应。
OBJECTIVE To explore electrophysiology mechanism of acupuncture for treatment and prevention of visual deprivation effect. METHODS Eighteen healthy 15-day Evans rats were randomly divided into a normal group, a model group and an acupuncture group, 6 rats in each one. Deprivation amblyopia model was established by monocular eyelid suture in the model group and acupuncture group. Acupuncture was applied at "Jingming" (BL 1), "Chengqi" (ST 1), "Qiuhou" (EX-HN 7) and "Cuanzhu" (BL 2) in the acupuncture group. The bilateral acupoints were selected alternately, one side for a day, and totally 14 days were required. The effect of acupuncture on visual evoked potential in different spatial frequencies was observed. METHODS Under three different kinds of spatial frequencies of 2 X 2, 4 X 4 and 8 X 8, compared with normal group, there was obvious visual deprivation effect in the model group where P1 peak latency was delayed (P0.05). Under spatial frequency of 4 X 4, N1-P1 amplitude value was maximum in the normal group and acupuncture group. With this spatial frequency the rat's eye had best resolving ability, indicating it could be the best spatial frequency for rat visual system. CONCLUSION The visual system has obvious electrophysiology plasticity in sensitive period. Acupuncture treatment could adjust visual deprivation-induced suppression and slow of visual response in order to antagonism deprivation effect.