Incidence of toxoplasma retinochoroiditis in patients after using TNF-α blockers
Incidence of toxoplasma retinochoroiditis in patients after using TNF-α blockers
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DOI：
10.1016/j.parint.2013.02.003
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发表时间：
2013-06-01
影响因子：
1.9
通讯作者：
Pinheiro, Marcelo M.
中科院分区：
文献类型：
--
作者：
de Paula Rodrigues, Kelly Fernandes;Faria e Arantes, Tiago Eugenio;Pinheiro, Marcelo M.
TNE-α阻滞剂与潜伏性肉芽肿感染的再激活有关，几乎6%的世界人口患有由弓形虫引起的某些脉络膜视网膜炎（CR）。因此，TNF-α的阻断可以重新激活潜伏的弓形虫感染（LTxl）。本研究旨在评估与T相关的慢性和活动性CR的患病率和发生率。强直性脊柱炎（AS）患者的弓形虫感染。在一项前瞻性对照试验中，将37例开始TNF α阻滞剂治疗的活动性AS门诊患者的74只眼与35例年龄和性别匹配的常规治疗AS患者进行了比较。所有患者均进行了T.在12个月内进行定期眼科检查。活动性CR定义为视网膜脉络膜病变伴玻璃体炎症的白色病灶，边缘锐利、色素沉着、中心萎缩的视网膜脉络膜病变定义为CR瘢痕。基线时，无患者发生活动性CR。从144只眼睛检查，几乎6%有CR疤痕，只有2.1%有典型的弓形体CR疤痕，他们都是阴性的HLA-B27。在12个月的随访中，没有观察到复发或新的CR。使用TNF-α阻滞剂的AS患者并不具有由T.刚地。(C)2013爱思唯尔爱尔兰有限公司版权所有。
TNE-alpha blockers are associated with reactivation of latent granulomatous infections and almost 6% of the world population has some chorioretinitis (CR) caused by Toxoplasma gondii. Thus, the blockade of TNF-alpha could reactivate a latent toxoplasmosis infection (LTxl). This study was conducted to evaluate the prevalence and incidence of chronic and active CR related to T. gondii in patients with ankylosing spondylitis (AS). A total of 74 eyes from 37 active AS outpatients starting TNF alpha blockers were compared with 35 AS patients, matched to age and sex, under conventional therapy in a prospective and controlled trial. All patients underwent serological tests for T. gondii, as well as periodic ophthalmologic examination during 12 months. Active CR was defined if a white, focal retinochoroidal lesion with overlying vitreous inflammation had been found. Retinochoroidal lesions with sharp edges, hyperpigmented borders and atrophic center were defined as CR scars. At baseline, no patient had active CR. From the 144 eyes examined, almost 6% had CR scars and only 2.1% had a typical toxoplasmic CR scar and all of them were negative for HLA-B27. During 12 months of follow-up, no recurrence or new CR were observed. AS patients using TNF-alpha blockers do not have a higher risk of acute or chronic CR caused by T. gondii. (C) 2013 Elsevier Ireland Ltd. All rights reserved.