The evolution of strategy in bacterial warfare via the regulation of bacteriocins and antibiotics.
The evolution of strategy in bacterial warfare via the regulation of bacteriocins and antibiotics.
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DOI：
10.7554/elife.69756
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发表时间：
2021-09-07
期刊：
影响因子：
7.7
通讯作者：
Foster KR
中科院分区：
文献类型：
--
作者：
Niehus R;Oliveira NM;Li A;Fletcher AG;Foster KR
细菌通过一系列不同的化合物相互抑制和杀死，包括细菌素和抗生素。这些攻击受到高度监管，但我们对这种监管背后的进化逻辑缺乏清晰的理解。在这里，我们将联合收割机一个详细的细菌竞争动态模型与进化博弈论相结合，研究细菌战争的规则。我们基于细菌调控网络的分子生物学，对大范围的可能的作战策略进行建模。我们的模型预测，受管制的策略，使用群体感应或压力反应，以调节毒素的生产，将很容易演变，因为他们胜过组成型毒素生产。在调控策略中，我们发现一个特别成功的策略是上调毒素的产生，以响应传入的竞争对手的毒素，这可以通过检测细胞损伤（竞争传感）的应激反应来实现。我们的工作奇迹般地揭示了互惠的一个基本优势，这是经典博弈论的一个分支。然而，与经典的结果相反，我们认为，细菌的互惠不是为了促进和平的结果，而是为了实现高效和有效的攻击。
Bacteria inhibit and kill one another with a diverse array of compounds, including bacteriocins and antibiotics. These attacks are highly regulated, but we lack a clear understanding of the evolutionary logic underlying this regulation. Here, we combine a detailed dynamic model of bacterial competition with evolutionary game theory to study the rules of bacterial warfare. We model a large range of possible combat strategies based upon the molecular biology of bacterial regulatory networks. Our model predicts that regulated strategies, which use quorum sensing or stress responses to regulate toxin production, will readily evolve as they outcompete constitutive toxin production. Amongst regulated strategies, we show that a particularly successful strategy is to upregulate toxin production in response to an incoming competitor’s toxin, which can be achieved via stress responses that detect cell damage (competition sensing). Mirroring classical game theory, our work suggests a fundamental advantage to reciprocation. However, in contrast to classical results, we argue that reciprocation in bacteria serves not to promote peaceful outcomes but to enable efficient and effective attacks.