CORTICOTROPIN-RELEASING FACTOR IN THE LOCUS-COERULEUS MEDIATES EEG ACTIVATION-ASSOCIATED WITH HYPOTENSIVE STRESS
CORTICOTROPIN-RELEASING FACTOR IN THE LOCUS-COERULEUS MEDIATES EEG ACTIVATION-ASSOCIATED WITH HYPOTENSIVE STRESS
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DOI：
10.1016/0304-3940(93)90862-f
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发表时间：
1993-12-24
影响因子：
2.5
通讯作者：
VALENTINO, RJ
中科院分区：
文献类型：
--
作者：
PAGE, ME;BERRIDGE, CW;VALENTINO, RJ
虽然促肾上腺皮质激素释放因子（CRF）被认为是在低血压应激时激活蓝斑（LC）的一种神经递质，但CRF激活LC的后果尚不清楚。在本研究中，激活大鼠LC神经元的低血压刺激也产生皮层脑电图（EEG）相关的觉醒。局部滴注可乐定选择性双侧LC失活可预防与低血压相关的脑电图激活。此外，双侧LC输注CRF拮抗剂可阻止LC和EEG的激活。这些结果表明，CRF作为一种神经递质在应激状态下激活LC，对整个前脑电生理活动具有强大的调节作用。
Although corticotropin-releasing factor (CRF) is thought to act as a neurotransmitter to activate the locus coeruleus (LC) during hypotensive stress, the consequences of LC activation by CRF are unknown. In the present study a hypotensive challenge that activated rat LC neurons also produced cortical electroencephalographic (EEG) correlates of arousal. Selective, bilateral LC inactivation by local clonidine infusion prevented EEG activation associated with hypotension. Additionally, bilateral LC infusion of CRF antagonists prevented both LC and EEG activation by this challenge. These results indicate that CRF, acting as a neurotransmitter to activate LC during stress, has a powerful modulatory influence over global forebrain electrophysiological activity.