Historical Perspective on Familial Gastric Cancer.
Historical Perspective on Familial Gastric Cancer.
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DOI：
10.1016/j.jcmgh.2016.12.003
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发表时间：
2017-03
影响因子：
7.2
通讯作者：
Yurgelun MB
中科院分区：
文献类型：
--
作者：
Boland CR;Yurgelun MB
胃癌是世界范围内的一种常见疾病，通常与胃部获得性慢性炎症有关，在大多数情况下与幽门螺杆菌感染有关。一小部分病例发生在家族聚集性中，其中一些可能与特定的生殖系突变有关。本文回顾了目前对家族性胃癌认识的历史背景，重点讨论了遗传性弥漫性胃癌的实体，并综述了与其他一些家族遗传性疾病相关的胃癌的风险。
Gastric cancer is a common disease worldwide, typically associated with acquired chronic inflammation in the stomach, related in most instances to infection by Helicobacter pylori. A small percentage of cases occurs in familial clusters, and some of these can be linked to specific germline mutations. This article reviews the historical background to the current understanding of familial gastric cancer, focuses on the entity of hereditary diffuse gastric cancer, and also reviews the risks for gastric cancer related to a number of other familial genetic diseases.