POSTNATAL-DEVELOPMENT OF RENAL-FUNCTION IN PRE-TERM AND FULL-TERM INFANTS
POSTNATAL-DEVELOPMENT OF RENAL-FUNCTION IN PRE-TERM AND FULL-TERM INFANTS
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DOI：
10.1111/j.1651-2227.1981.tb05539.x
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发表时间：
1981-01-01
期刊：
影响因子：
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通讯作者：
ZETTERSTROM, R
中科院分区：
文献类型：
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作者：
APERIA, A;BROBERGER, O;ZETTERSTROM, R
本研究旨在检查胎龄（GA）对出生后肾功能发育的影响，并在早产（PT）婴儿（GA = 30-34周）和足月（FT）婴儿（GA = 39-41周）中进行。出生后1-35天。从自发排泄后收集的8小时尿样和毛细血管血样中，测定肌酐清除率（CCr）、β 2-微球蛋白排泄分数（FE β 2）和Na排泄分数（FENa）。在一些婴儿接受液体胃肠外，同时测定肌酐和菊粉的清除率。根据本研究判断，CCr是肾小球滤过率（GFR）的可靠指标。新生儿PT和FT的GFR几乎相同，但从0.3-1周龄开始，FT的GFR增加显著快于PT。从1-5周龄开始，PT和FT婴儿的GFR以大致相同的速率增加。PT组3-5周婴儿GFR绝对值低于FT组。在出生后的整个第1个月期间，PT婴儿的FE β 2高于FT婴儿，而在出生后的第1周期间，PT婴儿的FENa高于FT婴儿，这表明PT婴儿中至少在近端小管水平存在肾小球肾小管失衡。不同的成熟阶段将改变至少在出生后第一个月内肾脏适应子宫外生活的先决条件。在出生后的整个1个月内，必须特别注意PT患者的肾功能有限。
This study was designed to examine the effect of gestational age (GA) on the postnatal development of renal function and was performed in pre-term (PT) infants (GA = 30-34 wk) and in full-term (FT) infants (GA = 39-41 wk). Postnatal age ranged from 1-35 days. From 8 h urine samples collected after spontaneous voiding and a capillary blood sample, determinations was made of the clearance of creatinine (CCr), the fractional excretion of .beta.2-microglobulin (FE.beta.2) and the fractional excretion of Na (FENa). In some infants receiving fluid parenterally, simultaneous determinations were made of the clearance of creatinine and inulin. As judged from this study, CCr is a reliable indicator of the glomerular filtration rate (GFR). GFR was almost the same in newborn PT and FT but from 0.3-1 wk of age GFR increased significantly more rapidly in FT than in PT. From 1-5 wk of age GFR increased at approximately the same rate in PT and FT infants. The absolute value for GFR in 3-5 wk old infants was lower in PT than in FT. FE.beta.2 was higher in PT than in FT infants during the entire 1st month of life and FENa was higher in PT than in FT infants during the 1st week of life, suggesting a glomerular tubular imbalance at least at the level of the proximal tubule in PT infants. Different stages of maturation will alter the preconditions for the renal adaptation to extrauterine life during at least the 1st month of life. Special attention must be paid to the limited renal function in PT during their entire 1st month of life.