Stable stochastic dynamics in yeast cell cycle.
Stable stochastic dynamics in yeast cell cycle.
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DOI：
10.1529/biophysj.107.109991
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发表时间：
2007-07
影响因子：
3.4
通讯作者：
Y. Okabe;M. Sasai
中科院分区：
文献类型：
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作者：
Y. Okabe;M. Sasai
细胞中的化学反应受到强烈的随机波动的影响。一个重要的问题是，细胞的基本生理行为如何在这些嘈杂的扰动下保持稳定。本文建立了芽殖酵母细胞周期的随机模型，分析了噪声对芽殖酵母细胞周期振荡的影响。该模型预测了mRNA和蛋白质水平的强烈噪声，模拟的蛋白质水平解释了同步和异步细胞群体中观察到的噪声统计趋势。尽管蛋白质和mRNA水平存在强烈的噪音，但细胞周期足够稳定，可以将受到很大干扰的细胞带回生理周期振荡。该模型表明，连续出现的固定点是这种稳定的细胞周期的起源。
Chemical reactions in cells are subject to intense stochastic fluctuations. An important question is how the fundamental physiological behavior of the cell is kept stable against those noisy perturbations. In this study, a stochastic model of the cell cycle of budding yeast was constructed to analyze the effects of noise on the cell-cycle oscillation. The model predicts intense noise in levels of mRNAs and proteins, and the simulated protein levels explain the observed statistical tendency of noise in populations of synchronous and asynchronous cells. Despite intense noise in levels of proteins and mRNAs, the cell cycle is stable enough to bring the largely perturbed cells back to the physiological cyclic oscillation. The model shows that consecutively appearing fixed points are the origin of this stability of the cell cycle.