Development and Renewal of Intestinal Villi in Pigs
Development and Renewal of Intestinal Villi in Pigs
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DOI：
10.1007/978-3-7091-1328-8_3
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发表时间：
2013
期刊：
影响因子：
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通讯作者：
Huansheng Yang;X. Xiong;Yulong Yin
中科院分区：
文献类型：
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作者：
Huansheng Yang;X. Xiong;Yulong Yin
猪的胃肠道粘膜不仅是消化吸收食物的器官，而且在抵抗肠道内的致病菌和有毒物质方面起着重要作用。胃肠道粘膜的发育始于胚胎早期，并在整个生命过程中不断自我更新。它通过调节上皮细胞的增殖、生长停滞、分化和凋亡来维持体内平衡。此外，胃肠粘膜的发育和更新过程受到遗传、神经、激素和饮食等多种因素的影响，并受到断奶应激的干扰。猪胃肠道粘膜不是一种非常常见的实验模型，因此，本章中讨论的一些信息是从其他物种获得的。
The gastrointestinal mucosa of pig not only acts as an organ for diet digestion and absorption but also plays an important role in fighting against pathogenic bacteria and toxic substances presented in intestinal lumen. The development of gastrointestinal mucosa begins in the early embryo and self-renews during the whole life. Its homeostasis is preserved via regulating the proliferation, growth arrest, differentiation, and apoptosis of epithelial cell. Moreover, the developmental and renewal processes of gastrointestinal mucosa are regulated by various factors, such as genetic, neural, hormonal and dietary influences and disturbed by weaning stress. Pig gastrointestinal mucosa is not a very common experimental model, and therefore, some information discussed in this chapter is obtained from other species.