Neurorestorative therapies for stroke: underlying mechanisms and translation to the clinic.
Neurorestorative therapies for stroke: underlying mechanisms and translation to the clinic.
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DOI：
10.1016/s1474-4422(09)70061-4
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发表时间：
2009-05
期刊：
影响因子：
48
通讯作者：
Chopp, Michael
中科院分区：
文献类型：
--
作者：
Zhang, Zheng Gang;Chopp, Michael
实验性中风的基于细胞的恢复性治疗和药物治疗显著改善了功能结果。这些疗法针对几种类型的实质细胞(包括神经干细胞、脑内皮细胞、星形胶质细胞、少突胶质细胞和神经元)，导致促进缺血脑中的内源性神经发生、血管生成、轴突萌发和突触形成。这些恢复性事件之间的相互作用可能是改善功能结果的基础。这篇综述提供了基于细胞和药物的中风恢复性治疗的例子，这些治疗刺激了大脑的可塑性和功能恢复。讨论了由这些疗法激活的分子通路，这些通路通过血管生成、神经再生以及轴突和树突的可塑性来诱导受损脑组织的重塑。与神经保护疗法中治疗受损脑组织相比，在恢复性疗法中处理完整的脑组织以激发功能益处的简便性可能更容易帮助将恢复性疗法从实验室转化到临床。
Restorative cell-based and pharmacological therapies for experimental stroke substantially improve functional outcome. These therapies target several types of parenchymal cells (including neural stem cells, cerebral endothelial cells, astrocytes, oligodendrocytes, and neurons), leading to enhancement of endogenous neurogenesis, angiogenesis, axonal sprouting, and synaptogenesis in the ischaemic brain. Interaction between these restorative events probably underpins the improvement in functional outcome. This Review provides examples of cell-based and pharmacological restorative treatments for stroke that stimulate brain plasticity and functional recovery. The molecular pathways activated by these therapies, which induce remodelling of the injured brain via angiogenesis, neurogenesis, and axonal and dendritic plasticity, are discussed. The ease of treating intact brain tissue to stimulate functional benefit in restorative therapy compared with treating injured brain tissue in neuroprotective therapy might more readily help with translation of restorative therapy from the laboratory to the clinic.