Estrogen and/or calcium plus vitamin D increase mandibular bone mass
Estrogen and/or calcium plus vitamin D increase mandibular bone mass
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DOI：
10.1902/jop.2004.75.6.811
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发表时间：
2004-06-01
影响因子：
4.3
通讯作者：
Civitelli, R
中科院分区：
文献类型：
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作者：
Hildebolt, CF;Pilgram, TK;Civitelli, R
背景资料：我们以前曾报道，雌激素/激素替代疗法（E/HRT）对口腔骨密度有3年以上的有益影响，钙和维生素D补充剂的影响较小。在这里，我们报告下颌骨骨量为49名妇女（原队列135）谁继续在一个额外的2年，开放标签extension.Methods：绝经后妇女被随机分配到接受钙和维生素D加E/HRT，或钙和维生素D。结果：26名服用钙剂、维生素D和E/HRT 5年的妇女中有22名下颌骨骨量有小幅增加（0.35 ± 0.38%，P
Background: We have previously reported that estrogen/ hormone replacement therapy (E/HRT) has beneficial effects on oral bone density over 3 years and that calcium and vitamin D supplementation has a lesser effect. Here we report on mandibular bone mass for 49 women (of the original cohort of 135) who continued in an additional 2-year, open-label extension.Methods: Postmenopausal women were randomly assigned to receive calcium and vitamin D plus E/HRT, or calcium and vitamin D only. Regression analysis of mandibular bone mass over time was performed for each woman.Results: Twenty-two of 26 women who took calcium and vitamin D plus E/HRT for 5 years had small mandibular bone mass increases (0.35 0.38%, P