Idiopathic erythema multiforme: Evidence of underlying Janus kinase-signal transducer and activator of transcription activation and successful treatment with tofacitinib.
Idiopathic erythema multiforme: Evidence of underlying Janus kinase-signal transducer and activator of transcription activation and successful treatment with tofacitinib.
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DOI：
10.1016/j.jdcr.2016.10.009
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发表时间：
2016-11
影响因子：
--
通讯作者：
King BA
中科院分区：
文献类型：
--
作者：
Damsky W;King BA
多形性红斑是一种急性的、典型的自限性粘膜皮疹，其特征为独特的靶病变。在一部分患者中，EM具有更慢性的病程，具有复发性发作甚至持续性疾病。在其中一些患者中，EM与慢性感染有关，最常见的是单纯疱疹病毒（HSV），并对抗病毒治疗有反应。然而，在高达58%的患者中，病因不明，1并且在这些情况下治疗通常是困难的。
Erythema multiforme (EM) is an acute, typically self-limited mucocutaneous eruption characterized by distinctive target lesions. In a subset of patients, EM has a more chronic course, with recurrent episodes or even persistent disease. In some of these patients, EM is related to chronic infections, most commonly herpes simplex virus (HSV), and will respond to antiviral therapy. However, in up to 58% of patients, the etiology is unknown, 1 and in these cases treatment is often difficult.