Signaling Pathways Regulating the Expression of Prx1 and Prx2 in the Chick Mandibular Mesenchyme
Signaling Pathways Regulating the Expression of Prx1 and Prx2 in the Chick Mandibular Mesenchyme
复制标题
DOI：
10.1002/dvdy.21762
复制
发表时间：
2008-11-01
影响因子：
2.5
通讯作者：
Mina, Mina
中科院分区：
文献类型：
--
作者：
Doufexi, Aikaterini-El;Mina, Mina
Prx 1和Prx 2是显示在下颌突的形态发生中发挥冗余但必不可少的作用的aristaless相关的同源异型盒基因的成员。为了深入了解调节下颌间充质中Prx基因表达的信号通路，我们使用小鸡作为模型系统。我们研究了面部基因表达的模式和来自上皮细胞的信号对下颌间充质中Prx基因表达的作用。我们的研究结果表明，阶段依赖性的作用，下颌上皮的表达Prx在下颌间充质和提供证据的成纤维细胞和刺猬家族的成员来自下颌上皮的Prx基因在下颌间充质的表达的积极作用。我们的研究表明，内皮素-1信号来自间充质参与限制的表达Prx 2的内侧下颌间充质。发展动力学237.3115- 3127，2008. (C)2008 Wiley-Liss，Inc.
Prx1 and Prx2 are members of the aristaless-related homeobox genes shown to play redundant but essential roles in morphogenesis of the mandibular processes. To gain insight into the signaling pathways that regulate expression of Prx genes in the mandibular mesenchyme, we used the chick as a model system. We examined the patterns of gene expression in the face and the roles of signals derived from the epithelium on the expression of Prx genes in the mandibular mesenchyme. Our results demonstrated stage-dependent roles of mandibular epithelium on the expression of Prx in the mandibular mesenchyme and provide evidence for positive roles of members of the fibroblast and hedgehog families derived from mandibular epithelium on the expression of Prx genes in the mandibular mesenchyme. Our studies suggest that endothelin-1 signaling derived from the mesenchyme is involved in restricting the expression of Prx2 to the medial mandibular mesenchyme. Developmental Dynamics 237.3115-3127,2008. (C) 2008 Wiley-Liss, Inc.