A re-examination of the role of basal forebrain cholinergic neurons in spatial working memory
A re-examination of the role of basal forebrain cholinergic neurons in spatial working memory
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DOI：
10.1016/s0028-3908(98)00032-x
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发表时间：
1998-04-01
影响因子：
4.7
通讯作者：
Gallagher, M
中科院分区：
文献类型：
--
作者：
Chappell, J;McMahan, R;Gallagher, M
基底前脑胆碱能系统，它支配广泛的皮质和边缘结构，传统上被认为是重要的学习和记忆。使用免疫毒素，192 IgG-皂草素，带来了这个功能指定的问题;基底前脑胆碱能神经元的选择性免疫损伤未能重现一些行为缺陷，观察到较少的选择性病变的方法。然而，最近的报告表明，在大鼠的空间工作记忆任务后，192 IgG-皂草素病变的位于内侧隔区（MSA）的胆碱能神经元的吻侧组观察到轻度损害。这些研究使用了一种损伤方案，其中将免疫毒素单次大体积注射到MSA中。在目前的研究中，在MSA中的胆碱能神经元的位置进行多次小注射，产生与早期研究中观察到的缺陷相当的胆碱能消耗。然而，在目前的研究中，胆碱能损伤的大鼠在空间工作记忆任务中没有损害，即使在60秒至8小时的延迟范围内施加。目前的报告表明，选择性地去除基底前脑中的胆碱能神经元可能不足以产生空间工作记忆的缺陷。(C)1998爱思唯尔科技有限公司版权所有。
The basal forebrain cholinergic system, which innervates widespread cortical and limbic structures; has traditionally been considered important for learning and memory. The use of an immunotoxin, 192 IgG-saporin, has brought this functional designation into question; selective immunolesions of basal forebrain cholinergic neurons have failed to reproduce a number of behavioral deficits that were observed with less selective lesion methods. Recent reports, however, have indicated that a mild impairment is observed in rats on a spatial working memory task after 192 IgG-saporin lesions of the rostral groups of cholinergic neurons located in the medial septal area (MSA). Those studies used a lesion protocol in which a single large volume injection of the immunotoxin was made into the MSA. In the current study, multiple small injections were made at the locations of cholinergic neurons in the MSA, producing a cholinergic depletion comparable to that reported in the earlier studies where deficits were observed. In the current study, however, rats with cholinergic lesions had no impairment in the spatial working memory task, even when delays ranging from 60 s to 8 h were imposed within.a trial. The current report indicates that selective removal of cholinergic neurons in the basal forebrain may not be sufficient to produce a deficit in spatial working memory. (C) 1998 Elsevier Science Ltd. All rights reserved.