Psoriasis and Dyslipidaemia: A Population-based Study
Psoriasis and Dyslipidaemia: A Population-based Study
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DOI：
10.2340/00015555-0510
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发表时间：
2008-01-01
影响因子：
3.6
通讯作者：
Cohen, Arnon D.
中科院分区：
文献类型：
--
作者：
Dreiher, Jacob;Weitzman, Dahlia;Cohen, Arnon D.
以前的报告表明银屑病和代谢综合征之间的关联。本研究的目的是阐明银屑病和血脂异常之间的关系。利用基于人群的数据库进行横断面研究。银屑病患者与非银屑病患者的血脂异常患病率和血脂水平进行比较。对没有糖尿病、高血压和心血管疾病的“低风险”受试者子集进行脂质水平比较。该研究包括10，669名银屑病患者和22，996名无银屑病的受试者。银屑病患者血脂异常的患病率显著较高（比值比（OR）=1.48，95%置信区间（CI）1.40-1.55）。在控制混杂因素后，相关性仍然显著（OR=1.19，95%CI 1.12-1.26，p < 0.001）。在多变量分析的“低风险”子集，甘油三酯水平较高的银屑病患者和高密度脂蛋白胆固醇水平较低。这项研究支持以前的报告银屑病和血脂异常之间的关联。
Previous reports demonstrated an association between psoriasis and the metabolic syndrome. The aim of this study was to elucidate the association between psoriasis and dyslipidaemia. A cross-sectional study was performed utilizing a population-based database. Psoriasis patients were compared with enrollees without psoriasis regarding the prevalence of dyslipidaemia and lipid levels. Comparison of lipid levels was performed on a "low-risk" subset of subjects without diabetes, hypertension and cardiovascular disease. The study included 10,669 psoriasis patients and 22,996 subjects without psoriasis. The prevalence of dyslipidaemia was significantly higher in psoriasis patients (odds ratio (OR)=1.48, 95% confidence interval (CI) 1.40-1.55). The association remained significant after controlling for confounders (OR=1.19, 95% CI 1.12-1.26, p < 0.001). In multivariate analysis of the "low-risk" subset, triglyceride levels were higher in psoriasis patients and high-density lipoprotein cholesterol levels were lower. This study supports previous reports of an association between psoriasis and lipid abnormalities.