Differential selectivity of endothelium‐derived relaxing factor and nitric oxide in smooth muscle
Differential selectivity of endothelium‐derived relaxing factor and nitric oxide in smooth muscle
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平滑肌中内皮衍生舒张因子和一氧化氮的差异选择性
DOI：
10.1111/j.1476-5381.1987.tb11347.x
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发表时间：
1987
影响因子：
7.3
通讯作者：
B. Berkowitz
中科院分区：
文献类型：
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作者：
Kazuhisa Shikano;E. Ohlstein;B. Berkowitz
检测并比较内皮源性舒张因子（EDRF）和一氧化氮（NO）对平滑肌舒张的选择性。将培养的牛肺动脉内皮细胞（BPAE）释放EDRF和NO灌流于血管、气管、胃肠道和子宫平滑肌。EDRF松弛血管平滑肌，但不松弛气管、胃肠道或子宫平滑肌。血管和胃肠道平滑肌无松弛，但气管和子宫平滑肌无松弛。EDRF和NO对平滑肌的舒张作用具有不同的选择性
The selectivity of endothelium‐derived relaxing factor (EDRF) and nitric oxide (NO) on smooth muscle relaxation was examined and compared. EDRF released from bovine pulmonary arterial endothelium (BPAE) in culture and NO were superfused over vascular, tracheal, gastrointestinal and uterine smooth muscle. EDRF relaxed vascular smooth muscle but not tracheal, gastrointestinal or uterine smooth muscle. NO relaxed vascular and gastrointestinal smooth muscle but not tracheal or uterine smooth muscle. There was a differential selectivity between the relaxant effect of EDRF and NO on smooth muscle
影响因子：
--
作者：
RUBANYI, GM;VANHOUTTE, PM
通讯作者：
VANHOUTTE, PM