Interaction of the TNF homologues BLyS and APRIL with the TNF receptor homologues BCMA and TACI
Interaction of the TNF homologues BLyS and APRIL with the TNF receptor homologues BCMA and TACI
复制标题
DOI：
10.1016/s0960-9822(00)00566-2
复制
发表时间：
2000-06-29
期刊：
影响因子：
9.2
通讯作者：
Ashkenazi, A
中科院分区：
文献类型：
--
作者：
Marsters, SA;Yan, MH;Ashkenazi, A
BLyS（也称为TALL-1、THANK或BAFF）[1-4]是肿瘤坏死因子（TNF）基因家族的一员，可刺激B细胞增殖和产生免疫球蛋白。BLyS与TNF受体（TNFR）同源物TACI（跨膜激活因子和caml相互作用因子）[5]相互作用，用TACI- fc融合蛋白处理小鼠可消除抗原攻击[6]后生发中心的形成。在这里，我们报道了BLyS与另一种TNFR同源物BCMA （B细胞成熟抗原）之间的一种新的相互作用[7,8]。此外，TNF同源物APRIL[9]是BLyS的近亲，也与BCMA和TACI结合。BLyS或APRIL通过TACI和BCMA激活核因子κ B (nf - κ B)，每种配体均刺激外周血B细胞产生免疫球蛋白M （IgM）。这些结果确定了一个可能在体液免疫中起重要作用的双配体-受体系统。(C) 2000 Elsevier Science Ltd.版权所有。
BLyS (also called TALL-1, THANK, or BAFF) [1-4] is a member of the tumor necrosis factor (TNF) gene family that stimulates proliferation and immunoglobulin production by B cells. BLyS interacts with the TNF receptor (TNFR) homologue TACI (transmembrane activator and CAML-interactor) [5], and treatment of mice with a TACI-Fc fusion protein abolishes germinal center formation after antigenic challenge [6]. Here we report a novel interaction between BLyS and another TNFR homologue, BCMA (B cell maturation antigen) [7,8]. Further, the TNF homologue APRIL [9], a close relative of BLyS, also bound to BCMA and TACI. BLyS or APRIL activated nuclear factor-kappa B (NF-kappa B) through TACI and BCMA, and each ligand stimulated immunoglobulin M (IgM) production by peripheral blood B cells. These results define a dual ligand-receptor system that may play an important role in humoral immunity. (C) 2000 Elsevier Science Ltd. All rights reserved.