Environmental Immunology: Lessons Learned from Exposure to a Select Panel of Immunotoxicants.
Environmental Immunology: Lessons Learned from Exposure to a Select Panel of Immunotoxicants.
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DOI：
10.4049/jimmunol.1502149
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发表时间：
2016-04-15
期刊：
影响因子：
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通讯作者：
Shepherd DM
中科院分区：
文献类型：
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作者：
Kreitinger JM;Beamer CA;Shepherd DM
暴露于环境污染物会对免疫系统产生深远的影响。许多不同种类的外源性物质可以显著抑制或增强免疫反应，这取决于暴露的水平（即剂量）和背景（即时间，途径）。虽然确定毒物对免疫系统的影响是改善公共卫生的重要组成部分，但环境免疫学极大地增强了我们对免疫系统如何发挥作用的理解，并探索新的免疫疗法。这篇简要综述着重于三个不同的例子，说明免疫毒理学如何使免疫学领域受益，介绍了（A）芳烃受体（AhR）信号通路，（B）纳米材料的免疫调节作用，以及（C）外源性暴露对免疫系统发育的影响。总的来说，免疫毒理学的贡献显着增强了公共卫生，并刺激了基础和应用免疫学的重大进展。
Exposure to environmental contaminants can produce profound effects on the immune system. Many different classes of xenobiotics can significantly suppress or enhance immune responsiveness depending on the levels (i.e. dose) and context (i.e. timing, route) of exposure. While defining the effects that toxicants can have on the immune system is a valuable component to improving public health, environmental immunology has greatly enhanced our understanding of how the immune system functions and explore new immunotherapies. This Brief Review focuses on three different examples of how immunotoxicology has benefitted the field of immunology, presenting information on (A) the aryl hydrocarbon receptor (AhR) signaling pathway, (B) the immunomodulatory effects of nanomaterials, and (C) the impact of xenobiotic exposure on the developing immune system. Collectively, contributions from immunotoxicology have significantly enhanced public health and spurred seminal advances in both basic and applied immunology.