Chronic infusion of nicotine can increase operant self-administration of alcohol
Chronic infusion of nicotine can increase operant self-administration of alcohol
复制标题
DOI：
10.1016/s0028-3908(01)00037-5
复制
发表时间：
2001-07-01
影响因子：
4.7
通讯作者：
Little, HJ
中科院分区：
文献类型：
--
作者：
Clark, A;Lindgren, S;Little, HJ
研究了通过渗透微型泵连续输注给予尼古丁对大鼠酒精操作性自我给药的影响，采用可变间隔（15 s）时间表，并测量酒精反应的获得、维持、消退和恢复。0.25、1.25和7.5 mg/kg/24 h的尼古丁剂量对酒精反应的维持没有显着影响，但5 mg/kg/24 h尼古丁导致水替代时提供奖励的杠杆反应显着增加酒精。表明反应延迟消失。在输注2.5 mg/kg/24 h尼古丁期间，当提供酒精和蔗糖的混合物作为奖励时，在获得响应期间，响应显著大于“蔗糖褪色”训练课程。在获得酒精反应后植入2.5 mg/kg/24 h尼古丁微型泵，在尼古丁输注的第一周内，酒精反应增加，但相应的尼古丁输注剂量0.25，1.25和7.5无显著影响。结果表明，尼古丁可以增加酒精的操作性反应，这是至关重要的依赖于尼古丁的剂量和测试的时间。这些结果对经常遇到的酒精和尼古丁组合依赖有影响。(C)2001爱思唯尔科技有限公司版权所有。
Effects of nicotine, administered by continuous infusion via osmotic minipumps, were studied on the operant self-administration of alcohol by rats, using a variable interval (15 s) schedule, and measuring the acquisition, maintenance, extinction and reinstatement of responding for alcohol. Doses of nicotine of 0.25, 1.25 and 7.5 mg/kg/24 h had no significant effects on the maintenance of responding for alcohol, but 5 mg/kg/24 h nicotine resulted in a significant increase in responding on the lever delivering the reward when water was substituted for the alcohol. indicating delayed extinction of responding. During infusion of 2.5 mg/kg/24 h nicotine, responding was significantly greater over the "sucrose-fading" training sessions, during acquisition of responding, when mixtures of alcohol and sucrose were provided as reward. When minipumps infusing 2.5 mg/kg/24 h nicotine were implanted after the alcohol responding had been acquired, the responding for alcohol increase during the first week of nicotine infusion, but corresponding nicotine infusion doses of 0.25, 1.25 and 7.5 had no significant effects. The results indicate that nicotine can increase operant responding for alcohol and this is crucially dependent on the dose of nicotine and the time of testing. The results have implications for the frequently encountered dependence on the combination of alcohol and nicotine. (C) 2001 Elsevier Science Ltd. All rights reserved.