Radical-clock α-halo-esters as mechanistic probes for bisphosphine iron-catalyzed cross-coupling reactions
Radical-clock α-halo-esters as mechanistic probes for bisphosphine iron-catalyzed cross-coupling reactions
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DOI：
10.1016/j.tet.2018.11.043
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发表时间：
2019-01-11
期刊：
影响因子：
2.1
通讯作者：
Gutierrez, Osvaldo
中科院分区：
文献类型：
--
作者：
Liu, Lei;Lee, Wes;Gutierrez, Osvaldo
通过手性双膦铁催化的C（sp（2））-C（sp（3））交叉偶联反应，合成了新型的α-卤代自由基酯，并通过量子力学计算研究了反应机理.这些结果提供了深入了解的作用的基板（卤素和取代基）在竞争笼内和笼外芳基化途径，并提供了一个基础，为未来的合理设计的新型串联环化芳基化反应使用双膦铁作为催化剂。(C)2018爱思唯尔有限公司版权所有
The mechanism of chiral bisphosphine iron-catalyzed C(sp(2))-C(sp(3)) cross-coupling reactions has been studied via the synthesis of novel radical-clock alpha-halo-esters and quantum mechanical calculations. These results provide insights into the role of the substrate (halogen and substituents) in competing in-cage and out-of-cage arylation pathways and provide a basis for the future rational design of novel tandem cyclization-arylation reactions using bisphosphine-iron as catalysts. (C) 2018 Elsevier Ltd. All rights reserved.