Six-minute walk, maximal exercise tests - Reproducibility in fibrotic interstitial pneumonia
Six-minute walk, maximal exercise tests - Reproducibility in fibrotic interstitial pneumonia
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DOI：
10.1164/rccm.200405-578oc
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发表时间：
2005-05-15
影响因子：
24.7
通讯作者：
Wells, AU
中科院分区：
文献类型：
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作者：
Eaton, T;Young, P;Wells, AU
静息肺功能和运动变量被广泛用于特发性间质性肺炎（IIP）的分期和监测。然而，运动数据（最大运动量和6分钟步行试验）的变异性尚未得到明确评价。我们前瞻性地量化了纤维化IIP（特发性肺纤维化，纤维化非特异性间质性肺炎）的静息和运动功能数据的可重复性，并评估了变量之间的相互关系。连续30例纤维化IIP患者接受了一系列静息肺功能测试，6分钟步行（n = 29）和最大运动（n = 24），间隔1周，所有测试均按照美国胸科协会标准进行。受试者内6分钟步行距离的重现性极好（SD/均值= 4.2%），静息肺功能指数和最大运动试验的Vo（2）max的重现性在临床上可接受。然而，在6分钟步行和最大运动试验中，运动结束时氧饱和度下降幅度的可重复性较差（SD/平均值> 25%）。最大运动试验的最大摄氧量与6分钟步行距离之间存在高度显著的相关性（r（s）= 0.78，p < 0.0001）。在纤维化HIP中，6分钟步行距离的良好再现性是常规分期和监测的主要优势，而最大运动变量的再现性较差。
Resting pulmonary function and exercise variables are widely used to stage and monitor idiopathic interstitial pneumonia (IIP). However, the variability of exercise data (maximal exercise and the 6-minute walk test) has not been evaluated definitively. We have prospectively quantified the reproducibility of resting and exercise functional data in fibrotic IIP (idiopathic pulmonary fibrosis, fibrotic nonspecific interstitial pneumonia) and have evaluated interrelationships between variables. Thirty consecutive patients with fibrotic IIP underwent serial resting pulmonary function tests, 6-minute walk (n = 29), and maximal exercise (n = 24) at an interval of 1 week, with all testing performed in accordance with American Thoracic Society standards. Within-subject reproducibility was excellent for 6-minute walk distance (SD/mean = 4.2%) and clinically acceptable for resting pulmonary function indices and Vo(2)max on maximal exercise testing. However, the amplitude of oxygen desaturation at the end of exercise was poorly reproducible in both 6-minute walk and maximal exercise testing (SD/mean > 25%). There was a highly significant relationship between Vo2max on maximal exercise testing and 6-minute walk distance (r(s) = 0.78, p < 0.0001). In fibrotic HIP, the excellent reproducibility of the 6-minute walk distance is a major advantage in routine staging and monitoring, whereas maximal exercise variables are poorly reproducible.