Differences in early-phase tracer distribution in lung between 11C-acetate and 13N-ammonia
Differences in early-phase tracer distribution in lung between 11C-acetate and 13N-ammonia
复制标题
11C-乙酸盐和 13N-氨在肺部早期示踪剂分布的差异
DOI：
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发表时间：
2009
影响因子：
1.5
通讯作者：
H. Okazawa
中科院分区：
文献类型：
--
作者：
T. Kudo;T. Hata;S. Kagawa;Y. Kishibe;J. Iwasaki;H. Okazawa
Aim13N-ammonia and 11C-acetate are well-known tracers useful for the measurement of myocardial blood flow. Some studies reported that the measurement of 11C-acetate showed better statistical quality than that with 13N-ammonia. To evaluate this difference, we focused on the early-phase tracer kinetics in blood and lung. The tracer kinetics in the myocardium, arterial blood, venous blood, and lung were compared between these two tracers. Patients and methodsTwelve patients were studied. Dynamic positron emission tomography was performed with 11C-acetate and 13N-ammonia within a 1-week period. The time activity curves (TACs) of the myocardium, arterial blood, and lung were calculated. The TACs normalized to the peak activity of right ventricle blood (normalized TAC) were also generated. ResultsThe area under the curve of each TAC was calculated. Lung activity tended to be higher when assessed with 13N-ammonia. The area under the curve of the lung was larger with 13N-ammonia than with 11C-acetate both with the original TAC (478±232 vs. 248±87 MBq s/ml, P<0.001) and the normalized TAC (47.1±17.9 vs. 22.8±6.9 ratio×s, P<0.001). Conclusion13N-ammonia and 11C-acetate showed strikingly different early-phase tracer distribution in the lung. This difference may affect myocardial blood flow measurement, which largely depends on the early-phase image quality.
心脏直视手术后肺谷氨酰胺通量。
DOI：
10.1016/0022-4804(91)90074-v
发表时间：
1991
期刊：
The Journal of surgical research
影响因子：
--
作者：
Herskowitz,K;Plumley,DA;Martin,TD;Hautamaki,RD;Copeland3rd,EM;Souba,WW
通讯作者：
Souba,WW
心肌吸收碳 11 乙酸盐作为局部心肌血流量的间接估计。
DOI：
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发表时间：
1991
期刊：
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
影响因子：
--
作者：
Gropler,RJ;Siegel,BA;Geltman,EM
通讯作者：
Geltman,EM
使用氮-13-氨和动态 PET 量化心肌血流的简化方法。
DOI：
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发表时间：
1993
期刊：
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
影响因子：
--
作者：
Choi,Y;Huang,SC;Hawkins,RA;Kuhle,WG;Dahlbom,M;Hoh,CK;Czernin,J;Phelps,ME;Schelbert,HR
通讯作者：
Schelbert,HR