Eyeblink conditioning contingent on hippocampal theta enhances hippocampal and medial prefrontal responses
Eyeblink conditioning contingent on hippocampal theta enhances hippocampal and medial prefrontal responses
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DOI：
10.1152/jn.00801.2010
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发表时间：
2011-05-01
影响因子：
2.5
通讯作者：
Berry, Stephen D.
中科院分区：
文献类型：
--
作者：
Darling, Ryan D.;Takatsuki, Kanako;Berry, Stephen D.
Darling RD，Takatsuki K，Griffin AL，Berry SD.视海马theta为条件的眨眼条件反射增强海马和内侧前额叶反应。J Neurophysiol 105：2213-2224，2011.首次发表于2011年2月23日; doi：10.1152/jn.00801.2010.-跟踪眨眼经典条件反射（tEBCC）可以通过使训练试验取决于自然产生的海马3- 7-Hz θ节律来加速。然而，目前还不清楚θ波的存在（或不存在）如何影响海马内刺激驱动的变化，以及它如何与其他重要的痕迹调节结构（如内侧前额叶皮层（mPFC））中的神经活动模式相关。在本研究中，脑-机接口在theta的明确存在（T+）或不存在（T-）期间向兔子提供配对或非配对的条件反射试验，在T+配对组中产生显著更快的行为学习。刺激引起的海马单位反应更大，更有节奏的T+配对组。这种促进单位反应的补充海马局部场电位（LFP）的差异，与T+配对组表现出更多的连贯刺激诱发θ比T-配对动物和两个未配对组。快速学习T+配对组的mPFC单位反应显示出明显的抑制性/兴奋性顺序模式的反应的音调，没有看到在任何其他组。此外，持续的mPFC单位兴奋持续通过T+动物的跟踪间隔，但不是在T-动物。因此，θ-条件训练伴随着1）行为学习的加速，2）海马单元和LFP反应的增强，以及3）mPFC单元反应的增强。总之，这些数据提供的证据表明，试验前海马状态与支持tEBCC获得的分布式网络关键结构中增强的神经活动有关。
Darling RD, Takatsuki K, Griffin AL, Berry SD. Eyeblink conditioning contingent on hippocampal theta enhances hippocampal and medial prefrontal responses. J Neurophysiol 105: 2213-2224, 2011. First published February 23, 2011; doi: 10.1152/jn.00801.2010.-Trace eyeblink classical conditioning (tEBCC) can be accelerated by making training trials contingent on the naturally generated hippocampal 3- to 7-Hz theta rhythm. However, it is not well-understood how the presence (or absence) of theta affects stimulus-driven changes within the hippocampus and how it correlates with patterns of neural activity in other essential trace conditioning structures, such as the medial prefrontal cortex (mPFC). In the present study, a brain-computer interface delivered paired or unpaired conditioning trials to rabbits during the explicit presence (T+) or absence (T-) of theta, yielding significantly faster behavioral learning in the T+-paired group. The stimulus-elicited hippocampal unit responses were larger and more rhythmic in the T+-paired group. This facilitation of unit responses was complemented by differences in the hippocampal local field potentials (LFP), with the T+-paired group demonstrating more coherent stimulus-evoked theta than T--paired animals and both unpaired groups. mPFC unit responses in the rapid learning T+-paired group displayed a clear inhibitory/excitatory sequential pattern of response to the tone that was not seen in any other group. Furthermore, sustained mPFC unit excitation continued through the trace interval in T+ animals but not in T- animals. Thus theta-contingent training is accompanied by 1) acceleration in behavioral learning, 2) enhancement of the hippocampal unit and LFP responses, and 3) enhancement of mPFC unit responses. Together, these data provide evidence that pretrial hippocampal state is related to enhanced neural activity in critical structures of the distributed network supporting the acquisition of tEBCC.