Roles of Bronchopulmonary C-fibers in airway Hyperresponsiveness and airway remodeling induced by house dust mite.
Roles of Bronchopulmonary C-fibers in airway Hyperresponsiveness and airway remodeling induced by house dust mite.
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支气管肺泡C纤维在尘螨致气道高反应性和气道重塑中的作用
DOI：
10.1186/s12931-017-0677-8
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发表时间：
2017-11-29
影响因子：
5.8
通讯作者：
Fu Z
中科院分区：
文献类型：
--
作者：
Yang Z;Zhuang J;Zhao L;Gao X;Luo Z;Liu E;Xu F;Fu Z
哮喘以慢性气道炎症、气道高反应性（AHR）和气道重塑为特征。虽然屋尘螨（HDM）暴露是哮喘的常见原因，但HDM诱导的哮喘的发病机制尚未完全了解。支气管平滑肌C纤维（PCFs）主要通过释放神经肽（SP）参与神经源性炎症、病毒感染诱导的持续性AHR和卵清蛋白诱导的胶原沉积。然而，PCF在HDM诱导的哮喘的发病机制中的作用仍然未被探索。本研究的目的是确定PCF在产生这些特征中发挥的作用。我们比较了有和没有慢性HDM暴露的PCF完整和变性BALB/c小鼠（四组）的以下变量：1）AHR和肺SP; 2）气道平滑肌（ASM）质量; 3）肺部炎症细胞; 4）上皮增厚和粘液分泌。我们发现HDM诱发的AHR与肺SP和炎症的上调、ASM质量增加、上皮增厚和粘液高分泌有关。PCF变性降低了HDM诱导的AHR、肺SP和炎症以及ASM质量的变化，但未能显著影响上皮增厚和粘液高分泌。我们的数据表明PCF参与HDM通过气道炎症、AHR和气道重塑诱导过敏性哮喘的机制。
Asthma is characterized by chronic airway inflammation, airway hyperresponsiveness (AHR), and airway remodeling. While exposure of house dust mites (HDM) is a common cause of asthma, the pathogenesis of the HDM-induced asthma is not fully understood. Bronchopulmonary C-fibers (PCFs) contribute to the neurogenic inflammation, viral infection induced-persistent AHR, and ovalbumin induced collagen deposition largely via releasing neuropeptides, such as substance P (SP). However, PCF roles in the pathogenesis of the HDM-induced asthma remain unexplored. The goal of this study was to determine what role PCFs played in generating these characteristics. We compared the following variables among the PCF-intact and -degenerated BALB/c mice with and without chronic HDM exposure (four groups): 1) AHR and pulmonary SP; 2) airway smooth muscle (ASM) mass; 3) pulmonary inflammatory cells; and 4) epithelium thickening and mucus secretion. We found that HDM evoked AHR associated with upregulation of pulmonary SP and inflammation, ASM mass increase, epithelium thickenings, and mucus hypersecretion. PCF degeneration decreased the HDM-induced changes in AHR, pulmonary SP and inflammation, and ASM mass, but failed to significantly affect the epithelium thickening and mucus hypersecretion. Our data suggest an involvement of PCFs in the mechanisms by which HDM induces allergic asthma via airway inflammation, AHR, and airway remodeling.
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影响因子：
3.2
作者：
Grzela, Katarzyna;Zagorska, Wioletta;Krejner, Alicja;Litwiniuk, Malgorzata;Zawadzka-Krajewska, Anna;Banaszkiewicz, Aleksandra;Kulus, Marek;Grzela, Tomasz
通讯作者：
Grzela, Tomasz
影响因子：
--
作者：
LARSEN, GL;FAME, TM;GELFAND, EW
通讯作者：
GELFAND, EW
影响因子：
2.5
作者：
Liao G;Panettieri RA;Tang DD
通讯作者：
Tang DD
DOI：
10.1164/rccm.200308-1094oc
发表时间：
2004-02-01
影响因子：
24.7
作者：
Johnson, JR;Wiley, RE;Jordana, M
通讯作者：
Jordana, M
影响因子：
5.5
作者：
Amadesi, Silvia;Cottrell, Graeme S.;Bunnett, Nigel W.
通讯作者：
Bunnett, Nigel W.