Intramolecular Addition of a Dimethylamino C(sp3)-H Bond across C-C Triple Bonds Using IrCl(DTBM-SEGPHOS)(ethylene) Catalyst: Synthesis of Indoles from 2-Alkynyl-N-methylanilines
Intramolecular Addition of a Dimethylamino C(sp3)-H Bond across C-C Triple Bonds Using IrCl(DTBM-SEGPHOS)(ethylene) Catalyst: Synthesis of Indoles from 2-Alkynyl-N-methylanilines
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DOI：
10.1055/a-1511-1025
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发表时间：
2021-05-18
影响因子：
2.6
通讯作者：
Suginome, Michinori
中科院分区：
文献类型：
--
作者：
Ohmura, Toshimichi;Yagi, Kaito;Suginome, Michinori
在均三甲苯中，150 ℃下，一种新的铱配合物IrCl（DTBM-SEGPHOS）（C_2H_4）有效地催化了2-炔基-N，N-二甲基苯胺中二甲氨基的C（sp（3））-H键与C-C三键的分子内加成反应.分子内C（sp（3））-H加成后进行双键异构化，以良好至高产率得到3-取代吲哚。
Intramolecular addition of a C(sp(3))-H bond of the dimethylamino group across the C-C triple bond in 2-alkynyl-N,N-dimethylanilines is effectively catalyzed by a new iridium complex, IrCl(DTBM-SEGPHOS)(C2H4), in mesitylene at 150 degrees C. The intramolecular C(sp(3))-H addition is followed by double-bond isomerization to afford 3-substituted indoles in good to high yields.