The synchronous neural interactions test as a functional neuromarker for post-traumatic stress disorder (PTSD): a robust classification method based on the bootstrap
The synchronous neural interactions test as a functional neuromarker for post-traumatic stress disorder (PTSD): a robust classification method based on the bootstrap
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DOI：
10.1088/1741-2560/7/1/016011
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发表时间：
2010-02-01
影响因子：
4
通讯作者：
Engdahl, B.
中科院分区：
文献类型：
--
作者：
Georgopoulos, A. P.;Tan, H-R M.;Engdahl, B.
创伤经历会导致创伤后应激障碍(PTSD)，这是一种使人衰弱的疾病，目前还不存在生物标记物(医学研究所(US)2006年创伤后应激障碍：诊断和评估(华盛顿特区：国家科学院))。在这里，我们展示了同步神经相互作用(SNI)测试，该测试评估来自脑磁图(MEG)记录的神经种群之间的功能相互作用(Georgopoulos A P等2007 J.4349-55)可成功区分创伤后应激障碍患者和健康对照组。外部交叉验证，基于引导的分析产生了90%的总体分类准确率。此外，18名没有接受药物治疗的患者中，除一人外，所有患者的分类都是正确的。总之，这些发现证明了创伤后应激障碍和对照组之间大脑功能的显著差异，这些差异可用于鉴别诊断，并具有评估和监测疾病进展和治疗效果的潜力。
Traumatic experiences can produce post-traumatic stress disorder (PTSD) which is a debilitating condition and for which no biomarker currently exists (Institute of Medicine ( US) 2006 Posttraumatic Stress Disorder: Diagnosis and Assessment (Washington, DC: National Academies)). Here we show that the synchronous neural interactions (SNI) test which assesses the functional interactions among neural populations derived from magnetoencephalographic (MEG) recordings (Georgopoulos A P et al 2007 J. Neural Eng. 4 349-55) can successfully differentiate PTSD patients from healthy control subjects. Externally cross-validated, bootstrap-based analyses yielded >90% overall accuracy of classification. In addition, all but one of 18 patients who were not receiving medications for their disease were correctly classified. Altogether, these findings document robust differences in brain function between the PTSD and control groups that can be used for differential diagnosis and which possess the potential for assessing and monitoring disease progression and effects of therapy.