Engineering Self-assembly of Giant Molecules in the Condensed State Based on Molecular Nanoparticles
Engineering Self-assembly of Giant Molecules in the Condensed State Based on Molecular Nanoparticles
复制标题
基于分子纳米颗粒的凝聚态大分子工程自组装
DOI：
10.1039/c9sm01502g
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发表时间：
2019
期刊：
影响因子：
3.4
通讯作者：
Dong Xue-Hui
中科院分区：
文献类型：
--
作者：
Zhang Wei;Liu Yuchu;Huang Jiahao;Liu Tong;Xu Wei;Cheng Stephen Z D;Dong Xue-Hui
在生物系统中，众所周知，生物大分子的活性和功能不仅取决于其初级化学性质，还取决于其二级、三级和四级层次结构。在合成大分子中实现类似水平的控制仍有待证明。大多数与分子和层次结构相关的关键分子参数，如尺寸、组成、拓扑、序列和立体化学，都是异质的，这阻碍了对结构形成和操纵的探索和理解。或者，在过去的几年中，我们开发了一种基于分子纳米粒子的独特的巨分子系统，其中上述分子参数以及相互作用都被精确定义和控制。这些分子可以在本体、薄膜和溶液中自组装成无数非常规且独特的结构。因此，与小分子相比，巨分子提供了一个强大的平台，通过在放大的尺寸水平上精确和模块化地组装构建块来操纵分层结构。人们发现它们不仅在科学上有趣，而且在技术上也相关。
In biological systems, it is well-known that the activities and functions of biomacromolecules are dictated not only by their primary chemistries, but also by their secondary, tertiary, and quaternary hierarchical structures. Achieving control of similar levels in synthetic macromolecules is yet to be demonstrated. Most of the critical molecular parameters associated with molecular and hierarchical structures, such as size, composition, topology, sequence, and stereochemistry, are heterogenous, which impedes the exploration and understanding of structure formation and manipulation. Alternatively, in the past few years we have developed a unique giant molecule system based on molecular nanoparticles, in which the above-mentioned molecular parameters, as well as interactions, are precisely defined and controlled. These molecules could self-assemble into a myriad of unconventional and unique structures in the bulk, thin films, and solution. Giant molecules thus offer a robust platform to manipulate the hierarchical structures via precise and modular assemblies of building blocks in an amplified size level compared with small molecules. It has been found that they are not only scientifically intriguing, but also technologically relevant.