FUNCTION, MORPHOLOGY AND PROTEIN EXPRESSION OF AGING SKELETAL-MUSCLE - A CROSS-SECTIONAL STUDY OF ELDERLY MEN WITH DIFFERENT TRAINING BACKGROUNDS
FUNCTION, MORPHOLOGY AND PROTEIN EXPRESSION OF AGING SKELETAL-MUSCLE - A CROSS-SECTIONAL STUDY OF ELDERLY MEN WITH DIFFERENT TRAINING BACKGROUNDS
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DOI：
10.1111/j.1748-1716.1990.tb08974.x
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发表时间：
1990-09-01
期刊：
影响因子：
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通讯作者：
SALTIN, B
中科院分区：
文献类型：
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作者：
KLITGAARD, H;MANTONI, M;SALTIN, B
膝关节伸展的功能和形态/米。股外侧肌和肘屈曲/米。对年轻人（28 .+-. 0.1 岁，n = 7）和老年人（68 .+-. 0.5 岁，n = 8）久坐受试者以及老年游泳运动员（69 .+-. 1.9 岁，n = 6）、跑步者（70 .+-. 0.7 岁，n = 5）和力量训练受试者（68 .+-. 0.7 岁，n = 5）的肱二头肌进行了研究。 1.9 岁，n = 6)，跑步者 (70 .+-. 0.7 岁，n = 5) 和接受过力量训练的受试者 (68 .+-. 0.8 岁，n = 7)。平均而言，训练组在测量前的12-17年里，进行了训练方案（每周3±0.1次）。与年轻受试者相比，久坐的老年受试者的最大等长扭矩在膝关节伸展时低44%（P<0.05），在肘关节屈曲时低32%（P<0.05），运动速度在20%至26%之间（P<0.05）。 0.05) 膝关节伸展和肘关节弯曲均较低。横截面积m。股四头肌和肘屈肌也分别降低了 24% (P < 0.05) 和 20%，单位张力降低了 27% (P < 0.05) m。股四头肌降低 14%（P < 0.05），肘屈肌降低 14%。肌球蛋白重链型含量增加 27% (P < 0.05) 在 m 中观察到慢型肌球蛋白轻链 2 的含量高出 39% (P < 0.05)。与年轻受试者相比，久坐的老年受试者的股外侧肌。 m 也出现了同样的趋势。肱二头肌。由于组织化学纤维类型分布相同，并且没有观察到 I 型和 II 型肌球蛋白重链亚型的主要共表达 免疫细胞化学显示，随着年龄的增长，慢肌球蛋白亚型的增加似乎主要与 II 型纤维区域选择性萎缩引起的 I 型纤维相对面积增大有关。原肌球蛋白β-同种型的含量也随着衰老而增加。与游泳者和跑步者相比，接受过力量训练的老年受试者具有最大等长扭矩、速度 所研究的两块肌肉的运动、横截面积、特定张力以及肌球蛋白和原肌球蛋白亚型的含量与年轻对照组相同。这些结果似乎表明，力量训练可以抵消与年龄相关的衰老人类骨骼肌功能和形态的变化。
The functio and morphology of knee extension/m. vastus lateralis and elbow flexion/m. biceps branchi were studied in young (28 .+-. 0.1 years, n = 7) and elderly (68 .+-. 0.5 years, n = 8) sedentary subjects and in elderly swimmers (69 .+-. 1.9 years, n = 6), runners (70 .+-. 0.7 years, n = 5) and strength-trained subjects (68 .+-. 1.9 years, n = 6), runners (70 .+-. 0.7 years, n = 5) and strength-trained subjects (68 .+-. 0.8 years, n = 7). On average, the training groups had, for the 12-17 years before the measurements were taken, performed their training regimen (3 .+-. 0.1 times a week. Compared with the young subjects, the maximal isometric torque of the sedentary elderly subjects was 44% (P < 0.05) lower in knee extension and 32% (P < 0.05) lower in elbow flexion, and speed of movement was between 20 and 26% (P < 0.05) lower in both knee extension and elbow flexion. The cross-sectional area of m. quadriceps femoris and the elbow flexors was also 24% (P < 0.05) and 20% lower respectively, and the specific tension was 27% (P < 0.05) lower in m. quadriceps femoris and 14% (P < 0.05) lower in the elbow flexors. A 27% (P < 0.05) higher content of myosin heavy chain type I and 39% (P < 0.05) higher content of the slow-type myosin light chain-2 was observed in m. vastus lateralis of the sedentary elderly subjects as compared with the young subjects. The same tendency was also seen with m. biceps brachii. Since the histochemical fibre-type distribution was identical and no major co-expression of type I and type II myosin heavy-chain isoforms was observed with immunocytochemistry, the increase in slow myosin isoforms with ageing seems mainly related to a larger relative area of type I fibres induced by a selective atrophy of type II fibre area. An increased content of the .beta.-isoform of tropomyosin was also demonstrated with ageing. In contrast to the swimmers and runners, the elderly strength-trained subjects had maximal isometric torques, speed of movements, cross-sectional areas, specific tensions and a content of myosin and tropomyosin isoforms in both muscles studied identical to those of the young controls. These results seem to suggest that strength training can counteract the age-related changes in function and morphology of the ageing human skeletal muscle.