Renal clearance of fluoride in a steady state condition in man: influence of urinary flow and pH changes by diet.
Renal clearance of fluoride in a steady state condition in man: influence of urinary flow and pH changes by diet.
复制标题
人体稳态条件下肾脏对氟化物的清除：饮食对尿流量和 pH 值变化的影响。
DOI：
10.1111/j.1600-0773.1982.tb00982.x
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发表时间：
2009
期刊：
影响因子：
--
通讯作者：
M. Ehrnebo
中科院分区：
文献类型：
--
作者：
J. Ekstrand;C. Spak;M. Ehrnebo
为了研究氟化物的肾清除率，在两个独立的时期--在由富含蛋白质的饮食引起的酸性尿产生期间和在通过给予素食获得的碱性尿产生期间，每6小时给予4名受试者3 mg氟化物作为氟化钠片剂，持续60小时。在每次实验期间，每三小时收集一次血浆和尿液，持续72小时。在富含蛋白质的饮食期间，尿液pH值显着低于当受试者维持素食时。在高蛋白饮食实验中，尿氟排出量较低，但差异不显著。在两个实验期间，稳态下的血浆氟化物几乎相同。在这两种类型的实验中，肾氟清除率与尿pH值显著相关。当肾氟清除率与尿流量作图时，相关性仅在碱性条件下显着。两组实验之间的平均肾清除率无显著差异。可以得出结论，pH值和利尿都影响氟肾清除。此外，结果表明，饮食成分本身以某种方式影响肾脏对氟化物的清除。
In order to study fluoride renal clearance, four subjects were given 3 mg fluoride as sodium fluoride tablets every 6 hrs for 60 hrs during two separate periods - during production of acid urine induced by a protein rich diet and during production of alkaline urine obtained by giving a vegetarian diet. Plasma and urine were collected every third hour for 72 hours during each experiment. In the protein rich diet period urinary pH was significantly lower than when the subjects were maintained on the vegetarian diet. Lower urinary output of fluoride during the protein rich diet experiment was recorded, however, the difference was not significant. Plasma fluoride at steady state was almost the same during both experiments. Renal fluoride clearance was significantly correlated to urinary pH in both types of experiments. When renal fluoride clearance was plotted versus urinary flow, the correlation was only significant during alkaline conditions. The average renal clearance was not significantly different between the two sets of experiments. It may be concluded, that pH and diuresis both influences fluoride renal clearance. Moreover, the results suggests that dietary components as such, influence renal clearance of fluoride in some way or another.