Luqin-like RYamide peptides regulate food-evoked responses in C. elegans
Luqin-like RYamide peptides regulate food-evoked responses in C. elegans
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DOI：
10.7554/elife.28877
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发表时间：
2017-08
期刊：
影响因子：
7.7
通讯作者：
Hayao Ohno;Morikatsu Yoshida;Takahiro Sato;J. Kato;M. Miyazato;M. Kojima;T. Ida;Y. Iino
中科院分区：
文献类型：
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作者：
Hayao Ohno;Morikatsu Yoshida;Takahiro Sato;J. Kato;M. Miyazato;M. Kojima;T. Ida;Y. Iino
肽信号传导控制许多涉及多个器官的协调作用的过程，例如胃蛋白酶介导的食欲调节。然而，肽信号传导的作用模式在不同动物中保守的程度在很大程度上是未知的，因为许多肽和受体仍然是孤儿，许多未发现的肽仍然存在。在这里，我们确定了两个新的秀丽隐杆线虫神经肽，LURY-1 - 1和LURY-1 - 2，作为内源性配体的神经肽受体-22（NPR-22）。这两种肽均来源于与无脊椎动物luqin/精氨酸-酪氨酸-NH2（RYamide）前神经肽邻位的相同前体。LURY-1肽由两类咽神经元分泌，并控制与食物相关的过程：进食、寿命、产卵和运动行为。我们提出LURY-1肽将食物信号传递给NPR-22，NPR-22在进食起搏神经元和多巴胺能神经元中表达。我们的研究结果确定了一个关键的作用luqin类RYamides在摄食相关的过程中，并建议肽介导的负反馈是重要的饱腹调节在C。优雅的。
Peptide signaling controls many processes involving coordinated actions of multiple organs, such as hormone-mediated appetite regulation. However, the extent to which the mode of action of peptide signaling is conserved in different animals is largely unknown, because many peptides and receptors remain orphan and many undiscovered peptides still exist. Here, we identify two novel Caenorhabditis elegans neuropeptides, LURY-1-1 and LURY-1-2, as endogenous ligands for the neuropeptide receptor-22 (NPR-22). Both peptides derive from the same precursor that is orthologous to invertebrate luqin/arginine-tyrosine-NH2 (RYamide) proneuropeptides. LURY-1 peptides are secreted from two classes of pharyngeal neurons and control food-related processes: feeding, lifespan, egg-laying, and locomotory behavior. We propose that LURY-1 peptides transmit food signals to NPR-22 expressed in feeding pacemaker neurons and a serotonergic neuron. Our results identified a critical role for luqin-like RYamides in feeding-related processes and suggested that peptide-mediated negative feedback is important for satiety regulation in C. elegans.