Tetraspanins: Interactions and interplay with integrins
Tetraspanins: Interactions and interplay with integrins
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DOI：
10.1016/j.biocel.2012.01.020
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发表时间：
2012-05-01
影响因子：
4
通讯作者：
Cingolani, Lorenzo A.
中科院分区：
文献类型：
--
作者：
Bassani, Silvia;Cingolani, Lorenzo A.
Tetraspanins是一种小跨膜蛋白，存在于几乎所有真核细胞的细胞表面。通过与其他跨膜和细胞内蛋白的结合，它们调节从细胞黏附和运动到突触形成和肿瘤进展的各种细胞过程。在这里，我们提供一个分子，细胞和临床研究的简要概述，以说明这一迷人的分子家族的多重功能如何源于它们与多个分子伙伴的相互作用。特别是，我们强调了在健康和疾病中，Tetraspanins和细胞黏附分子整合素在调节细胞生理方面的特殊关系。(C)2012爱思唯尔有限公司。保留所有权利。
Tetraspanins are small transmembrane proteins present on the cell surface of almost every eukaryotic cell. Through binding with other transmembrane and intracellular proteins, they regulate diverse cellular processes ranging from cell adhesion and motility to synapse formation and tumor progression. Here, we provide a brief overview of molecular, cellular and clinical studies to illustrate how the multiple functions of this fascinating family of molecules stem from their interplay with multiple molecular partners. In particular, we emphasize the special relationship between tetraspanins and the cell adhesion molecules integrins in regulating cell physiology in health and disease. (c) 2012 Elsevier Ltd. All rights reserved.